Akpek E K, Polcharoen W, Ferry J A, Foster C S
Ocular Immunology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA.
Ophthalmology. 1999 Apr;106(4):757-60. doi: 10.1016/S0161-6420(99)90163-X.
Malignant lesions of the conjunctiva may present with slowly evolving signs resembling inflammation. The authors describe the clinical and histopathologic findings of two patients with bilateral conjunctival lymphoma who presented with a history of chronic conjunctivitis without clinically noticeable subconjunctival nodules.
Case report.
Two patients.
Both patients underwent conjunctival biopsy for evaluation of persistent conjunctival inflammation that did not respond to various medical treatment methods.
Histopathologic examination revealed extranodal marginal zone B-cell lymphoma (mucosa-associated lymphoid tissue type) in one patient and follicle center lymphoma in the other patient. Both patients subsequently received radiation therapy and achieved a complete remission with no evidence of recurrence in the follow-up period of 20 and 16 months, respectively.
Conjunctival lymphoma should be included in the differential diagnoses of chronic conjunctivitis. Persisting signs and symptoms of conjunctivitis not responding to standard treatment should prompt biopsy.
结膜恶性病变可能表现为类似炎症的缓慢进展体征。作者描述了两名双侧结膜淋巴瘤患者的临床和组织病理学表现，这两名患者均有慢性结膜炎病史，且临床上未发现明显的结膜下结节。
病例报告。
两名患者。
两名患者均接受了结膜活检，以评估对各种治疗方法均无反应的持续性结膜炎症。
组织病理学检查显示，一名患者为结外边缘区B细胞淋巴瘤（黏膜相关淋巴组织型），另一名患者为滤泡中心淋巴瘤。两名患者随后均接受了放射治疗，并分别在20个月和16个月的随访期内实现了完全缓解，且无复发迹象。
结膜淋巴瘤应纳入慢性结膜炎的鉴别诊断。对标准治疗无反应的结膜炎持续体征和症状应促使进行活检。
