Azarov V I, Hrabovs'kyĭ L O, Moĭbenko O O
A. A. Bogomoletz Institute of Physiology, NAS, Ukraine.
Fiziol Zh (1994). 1999;45(1-2):26-34.
The purpose of the present investigation was to determine the action of intra-coronary infusion of serotonin on collateral blood flow in dog heart. Intra-coronary injection of serotonin elicited a cardiogenic hypertensive chemoreflex and transient but marked reductions of collateral blood flow. The cardiac and circulatory effects of the hypertensive cardiogenic chemoreflex and reductions of collateral blood flow abolished by sectioning of the cervical vagi. These data indicate that serotonin act on blood flow in collateral-dependent tissue of ischemic dog heart.
本研究的目的是确定冠状动脉内注入血清素对犬心脏侧支血流的作用。冠状动脉内注射血清素引发心源性高血压化学反射以及侧支血流短暂但显著的减少。通过切断颈迷走神经可消除高血压心源性化学反射的心脏和循环效应以及侧支血流的减少。这些数据表明血清素对缺血犬心脏侧支依赖组织中的血流有作用。
