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在德国灵长类动物中心的非人灵长类动物身上观察到的胃肠道肿瘤。

Gastrointestinal tumors observed in nonhuman primates at the German primate center.

作者信息

Brack M

机构信息

Department of Pathology, German Primate Center, Göttingen.

出版信息

J Med Primatol. 1998 Dec;27(6):319-24. doi: 10.1111/j.1600-0684.1998.tb00082.x.

Abstract

Twenty-six gastrointestinal tumors were observed in twenty-three nonhuman primates during routine necropsies at the German Primate Center, Göttingen. The majority (15 cases) were colorectal mucoid adenocarcinomas in cotton-top tamarins (Saguinus oedipus), which in two animals were associated with gastric adenomas. Three cases of small intestinal mucoid adenocarcinomas occurred in common marmosets (Callithrix jacchus). One colonic leiomyoma was observed in a dwarf galago (Galagoides demidovii) and another one in a cotton top tamarin. Singular findings were a tubular adeno-carcinoma of the ileo-caecal valve in a saddle-backed tamarin (Saguinus fuscicollis) and a lymphosarcoma of jejunum, ileum, and colon in another saddle-backed tamarin. Multiple tubular adeno-carcinomas of the colonic diverticles occurred in an aged rhesus monkey (Macaca mulatta). The findings are discussed in comparison to the situation in man.

摘要

在位于哥廷根的德国灵长类动物中心进行常规尸检期间,在23只非人灵长类动物身上观察到了26例胃肠道肿瘤。其中大多数(15例)是棉顶狨猴(Saguinus oedipus)的结直肠黏液腺癌,在两只动物中还伴有胃腺瘤。普通狨猴(Callithrix jacchus)出现了3例小肠黏液腺癌。在一只倭丛猴(Galagoides demidovii)和一只棉顶狨猴中分别观察到1例结肠平滑肌瘤。罕见的发现包括一只鞍背狨猴(Saguinus fuscicollis)的回盲瓣管状腺癌,以及另一只鞍背狨猴的空肠、回肠和结肠淋巴肉瘤。一只老年恒河猴(Macaca mulatta)的结肠憩室出现了多个管状腺癌。本文将这些发现与人类的情况进行了比较讨论。

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