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胰腺导管内乳头状黏液性肿瘤

Intraductal papillary mucinous tumor of the pancreas.

作者信息

Siech M, Tripp K, Schmidt-Rohlfing B, Mattfeldt T, Görich J, Beger H G

机构信息

Department of General Surgery, University of Ulm, Germany.

出版信息

Am J Surg. 1999 Feb;177(2):117-20. doi: 10.1016/s0002-9610(98)00315-8.

DOI:10.1016/s0002-9610(98)00315-8
PMID:10204552
Abstract

BACKGROUND

Since 1996 the classification of pancreatic tumors was replaced by the new World Health Organization nomenclature. Formerly mucinous cystadenomas are now distinguished between intraductal papillary mucinous tumors of the pancreas (IPMT) and mucinous cystadenomas.

METHODS

We reevaluated the pathological specimen and surgical therapy of 23 consecutive patients and followed up these patients up for 4 years in median. Between 1987 and 1997 we treated 8 patients with IPMT and 15 patients with mucinous cystadenomas.

RESULTS

Eighty-five per cent of all patients were symptomatic. Ultrasonography and computed tomography were the most sensitive diagnostic techniques. In 25%, the entire pancreas was involved with IPMT; that was not the case in any of the patients with mucinous cystadenoma. All patients were resected with no perioperative mortality. After dismissal from the hospital, all resected patients are still alive after a median follow-up of 4 years. In no patient with IPMT, but in 1 patient with mucinous cystadenoma, the tumor recurred.

CONCLUSION

Surgical resection is the treatment of choice in all cystic tumors, and the late outcome of IPMT is as good as for mucinous cystadenoma.

摘要

背景

自1996年起,胰腺肿瘤的分类被世界卫生组织的新命名法所取代。以前的黏液性囊腺瘤现在被区分为胰腺导管内乳头状黏液性肿瘤(IPMT)和黏液性囊腺瘤。

方法

我们重新评估了连续23例患者的病理标本和手术治疗情况,并对这些患者进行了中位时间为4年的随访。在1987年至1997年期间,我们治疗了8例IPMT患者和15例黏液性囊腺瘤患者。

结果

所有患者中有85%出现症状。超声检查和计算机断层扫描是最敏感的诊断技术。25%的IPMT患者整个胰腺受累;黏液性囊腺瘤患者中无一例出现这种情况。所有患者均接受了手术切除,无围手术期死亡。出院后,所有接受手术切除的患者在中位随访4年后仍存活。IPMT患者中无一例肿瘤复发,但1例黏液性囊腺瘤患者出现肿瘤复发。

结论

手术切除是所有囊性肿瘤的首选治疗方法,IPMT的远期疗效与黏液性囊腺瘤相同。

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1
Intraductal papillary mucinous tumor of the pancreas.胰腺导管内乳头状黏液性肿瘤
Am J Surg. 1999 Feb;177(2):117-20. doi: 10.1016/s0002-9610(98)00315-8.
2
Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumor and mucinous cystic tumor.胰腺囊性肿瘤:一项关于导管内乳头状黏液性肿瘤和黏液性囊性肿瘤的日本多机构研究。
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Spleen-preserving distal pancreatectomy for intraductal papillary-mucinous tumor (IPMT).保留脾脏的远端胰腺切除术治疗导管内乳头状黏液性肿瘤(IPMT)。
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Gastroenterol Res Pract. 2014;2014:269803. doi: 10.1155/2014/269803. Epub 2014 Sep 4.
2
Intraductal papillary mucinous neoplasm of the pancreas: an update.胰腺导管内乳头状黏液性肿瘤:最新进展
Scientifica (Cairo). 2012;2012:893632. doi: 10.6064/2012/893632. Epub 2012 Nov 28.
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[Duodenum-preserving total pancreatic head resection : an organ-sparing operation technique for cystic neoplasms and non-invasive malignant tumors].
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Chirurg. 2013 May;84(5):412-20. doi: 10.1007/s00104-012-2423-6.
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Metachronous intraductal papillary mucinous neoplasm with carcinoma in situ of the pancreas arising within a short interval: report of a case.胰腺内短时间内发生的具有原位癌的同时性胰管内乳头状黏液性肿瘤:病例报告。
Surg Today. 2010 May;40(5):465-9. doi: 10.1007/s00595-008-4101-3. Epub 2010 Apr 28.
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Clinical presentation can predict disease course in patients with intraductal papillary mucinous neoplasm of the pancreas.临床表现可预测胰腺导管内乳头状黏液性肿瘤患者的疾病进程。
World J Surg. 2010 Jan;34(1):126-32. doi: 10.1007/s00268-009-0269-y.
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Intraductal papillary mucinous neoplasms of the pancreas.胰腺导管内乳头状黏液性肿瘤
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Outcomes of surgery for intraductal papillary mucinous neoplasms of the pancreas.胰腺导管内乳头状黏液性肿瘤的手术治疗结果
World J Surg. 2006 Oct;30(10):1909-14; discussion 1915. doi: 10.1007/s00268-006-0051-3.
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Comparison of resected and non-resected intraductal papillary mucinous neoplasms of the pancreas.胰腺切除与未切除的导管内乳头状黏液性肿瘤的比较。
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