Immunoglobulin class switch recombination: will genetics provide new clues to mechanism?
作者信息
Maizels N
机构信息
Departments of Molecular Biophysics and Biochemistry, and Genetics, Yale University School of Medicine, New Haven, CT 06520-8024, USA.
出版信息
Am J Hum Genet. 1999 May;64(5):1270-5. doi: 10.1086/302393.
Abstract
摘要
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Somatic hypermutation and the three R's: repair, replication and recombination.体细胞高频突变与三个“R”：修复、复制和重组。
Mutat Res. 1999 Mar;436(2):157-78. doi: 10.1016/s1383-5742(99)00003-4.
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Biological implications of the DNA structures associated with disease-causing triplet repeats.与致病三联体重复相关的DNA结构的生物学意义。
Am J Hum Genet. 1999 Feb;64(2):346-53. doi: 10.1086/302271.
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The role of ATM in DNA damage responses and cancer.ATM在DNA损伤反应及癌症中的作用。
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Multiple ATM-dependent pathways: an explanation for pleiotropy.多种依赖ATM的途径：对多效性的一种解释。
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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.在缺乏磷酸肌醇3激酶p85α的情况下，B细胞发育和增殖受损。
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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.DNA末端连接蛋白在淋巴细胞生成和神经生成中均起关键作用。
Cell. 1998 Dec 23;95(7):891-902. doi: 10.1016/s0092-8674(00)81714-6.
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G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, A role for G-G pairing in immunoglobulin switch recombination.LR1及其亚基核仁素和不均一核糖核蛋白D与G4 DNA的结合，G-G配对在免疫球蛋白类别转换重组中的作用。
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