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小鼠胸腺细胞中V-(D)-J连接信号与转换重复序列重组产生的环状DNA。

Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes.

作者信息

Davis D D, Yoshida K, Kingsbury L, Sakano H

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley 94720.

出版信息

J Exp Med. 1991 Mar 1;173(3):743-6. doi: 10.1084/jem.173.3.743.

DOI:10.1084/jem.173.3.743
PMID:1900083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2118817/
Abstract

During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)-J joining and a repetitive sequence for class switching. The molecular mechanisms that generate "hybrid circles" are discussed.

摘要

在分析小鼠胸腺细胞中环状DNA的过程中，利用免疫球蛋白重链连接基因和转换区探针鉴定出了新型重组体。这些环状物代表了V-(D)-J连接的七聚体-九聚体基序与类别转换的重复序列之间重组的切除产物。本文讨论了产生“杂交环”的分子机制。

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1
Circular DNA resulting from recombination between V-(D)-J joining signals and switch repetitive sequences in mouse thymocytes.小鼠胸腺细胞中V-(D)-J连接信号与转换重复序列重组产生的环状DNA。
J Exp Med. 1991 Mar 1;173(3):743-6. doi: 10.1084/jem.173.3.743.
2
Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.
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3
V(D)J recombination generates a high frequency of nonstandard TCR D delta-associated rearrangements in thymocytes.V(D)J重排在胸腺细胞中产生高频的非标准TCR Dδ相关重排。
J Immunol. 1993 Mar 15;150(6):2222-30.
4
Circular DNA is excised by immunoglobulin class switch recombination.环状DNA通过免疫球蛋白类别转换重组被切除。
Cell. 1990 Jul 13;62(1):143-9. doi: 10.1016/0092-8674(90)90248-d.
5
Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching.细胞因子处理的小鼠脾细胞中形成的开关环状DNA：免疫球蛋白类别转换中分子内DNA缺失的证据。
Cell. 1990 Jul 13;62(1):135-42. doi: 10.1016/0092-8674(90)90247-c.
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T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining.胸腺细胞核环状DNA中的T细胞受体β基因序列：V-D-J连接中分子内DNA缺失的直接证据。
Cell. 1987 May 22;49(4):477-85. doi: 10.1016/0092-8674(87)90450-8.
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Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.免疫球蛋白V基因替换是由分子内DNA缺失机制引起的。
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Interallelic V(D)J trans-rearrangement within the beta T cell receptor gene is infrequent and occurs preferentially during attempted D beta to J beta joining.β 型 T 细胞受体基因内的等位基因间 V(D)J 转重排很少见，且优先发生在 Dβ 与 Jβ 连接尝试过程中。
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VH gene replacement in thymocytes.胸腺细胞中的VH基因置换
J Immunol. 2001 Jan 15;166(2):855-60. doi: 10.4049/jimmunol.166.2.855.

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2
DNA sequences at immunoglobulin switch region recombination sites.免疫球蛋白转换区重组位点的DNA序列。
Nucleic Acids Res. 1993 Feb 11;21(3):365-72. doi: 10.1093/nar/21.3.365.
3
Characterization of a lymphoblastoid line deleted for lambda immunglobulin genes.缺失λ免疫球蛋白基因的淋巴母细胞系的特性分析
Immunogenetics. 1995;41(6):359-65. doi: 10.1007/BF00163993.
4
Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.免疫球蛋白V基因替换是由分子内DNA缺失机制引起的。
EMBO J. 1992 Feb;11(2):611-8. doi: 10.1002/j.1460-2075.1992.tb05093.x.

本文引用的文献

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Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.免疫球蛋白重链基因D片段的鉴定及其在T淋巴细胞中的重排。
Nature. 1981 Apr 16;290(5807):565-70. doi: 10.1038/290565a0.
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Somatic generation of antibody diversity.抗体多样性的体细胞产生。
Nature. 1983 Apr 14;302(5909):575-81. doi: 10.1038/302575a0.
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Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.免疫球蛋白重链基因片段的连接：来自一条有三个D-JH融合证据的染色体的启示
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T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining.胸腺细胞核环状DNA中的T细胞受体β基因序列：V-D-J连接中分子内DNA缺失的直接证据。
Cell. 1987 May 22;49(4):477-85. doi: 10.1016/0092-8674(87)90450-8.
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Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining.两对重组信号足以引起免疫球蛋白V-（D）-J连接。
Science. 1987 Nov 20;238(4830):1134-8. doi: 10.1126/science.3120312.
6
Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma.在一个Ly 1+ B细胞淋巴瘤中，一个表达的免疫球蛋白重链基因与一个种系可变基因片段之间的重组。
Nature. 1986;322(6082):843-6. doi: 10.1038/322843a0.
7
A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.重链阴性（无）前B细胞中一种新型的VH到VHDJH连接机制导致重链产生。
Nature. 1986;322(6082):840-2. doi: 10.1038/322840a0.
8
Isolation of an excision product of T-cell receptor alpha-chain gene rearrangements.T细胞受体α链基因重排切除产物的分离
Nature. 1987;327(6119):242-3. doi: 10.1038/327242a0.
9
The role of chromosomal translocations in B- and T-cell neoplasia.染色体易位在B细胞和T细胞肿瘤形成中的作用。
Annu Rev Immunol. 1987;5:253-77. doi: 10.1146/annurev.iy.05.040187.001345.
10
V(D)J recombination: a functional definition of the joining signals.V(D)J重排：连接信号的功能定义。
Genes Dev. 1989 Jul;3(7):1053-61. doi: 10.1101/gad.3.7.1053.