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营养状况对髋部骨折后预后的影响。

The effects of nutritional status on outcome after hip fracture.

作者信息

Koval K J, Maurer S G, Su E T, Aharonoff G B, Zuckerman J D

机构信息

Department of Orthopaedic Surgery, Hospital for Joint Diseases, New York, New York 10003, USA.

出版信息

J Orthop Trauma. 1999 Mar-Apr;13(3):164-9. doi: 10.1097/00005131-199903000-00003.

Abstract

OBJECTIVE

To determine the effect of nutrition on patient outcome after hip fracture.

STUDY DESIGN

Retrospective review of prospectively collected data.

METHODS

Four hundred ninety hip fracture patients had albumin and total lymphocyte count levels determined at the time of admission and constituted the study population. These variables were examined as predictors for outcomes, including: in-hospital mortality, postoperative complications, hospital length of stay, hospital discharge status, one-year mortality rate, ambulatory ability, and independence in basic and instrumental activities of daily living twelve months after surgery.

RESULTS

Eighty-seven patients (18 percent) were found to be malnourished on hospital admission based on a preoperative albumin level of < 3.5 grams/deciliter, and 280 patients (57 percent) based on a total lymphocyte count of < 1,500 cells/milliliter. An albumin level of < 3.5 grams/deciliter was predictive for increased length of stay (p = 0.03) and for in-hospital mortality (p = 0.03). A total lymphocyte count < 1,500 cells/milliliter was predictive for one-year mortality (p < 0.01). Patients with abnormal albumin and total lymphocyte count were 2.9 times more likely to have a length of stay greater than two weeks (p = 0.03), 3.9 times more likely to die within one year after surgery (p = 0.02), and 4.6 times less likely to recover their prefracture level of independence in basic activities of daily living (p < 0.01). Neither parameter was predictive for patients developing a postoperative complication, hospital discharge status (home versus nursing home), recovery of prefracture ambulatory ability, or independence in instrumental activities of daily living at twelve-month follow-up.

CONCLUSION

Patients at risk for poor outcomes after hip fracture can be identified using relatively inexpensive laboratory tests such as albumin and total lymphocyte count.

摘要

目的

确定营养对髋部骨折患者预后的影响。

研究设计

对前瞻性收集的数据进行回顾性分析。

方法

490例髋部骨折患者在入院时测定了白蛋白和总淋巴细胞计数水平,构成研究人群。将这些变量作为预后的预测指标进行研究,包括:住院死亡率、术后并发症、住院时间、出院状态、一年死亡率、活动能力以及术后十二个月基本和工具性日常生活活动的独立性。

结果

根据术前白蛋白水平<3.5克/分升,87例患者(18%)入院时被发现营养不良;根据总淋巴细胞计数<1500个/毫升,280例患者(57%)营养不良。白蛋白水平<3.5克/分升可预测住院时间延长(p = 0.03)和住院死亡率(p = 0.03)。总淋巴细胞计数<1500个/毫升可预测一年死亡率(p < 0.01)。白蛋白和总淋巴细胞计数异常的患者住院时间超过两周的可能性高2.9倍(p = 0.03),术后一年内死亡的可能性高3.9倍(p = 0.02),术后十二个月基本日常生活活动恢复至骨折前独立水平的可能性低4.6倍(p < 0.01)。这两个参数均不能预测患者是否发生术后并发症、出院状态(回家与养老院)、骨折前活动能力的恢复或术后十二个月工具性日常生活活动的独立性。

结论

使用白蛋白和总淋巴细胞计数等相对廉价的实验室检查,可识别髋部骨折后预后不良风险的患者。

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