转移相关蛋白MTA1 mRNA在浸润性食管癌中的过表达。
Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas.
作者信息
Toh Y, Kuwano H, Mori M, Nicolson G L, Sugimachi K
机构信息
Division of Pathology, Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan.
出版信息
Br J Cancer. 1999 Apr;79(11-12):1723-6. doi: 10.1038/sj.bjc.6690274.
The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio > or = 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio > or = 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.
MTA1基因是最近鉴定出的一种新型乳腺癌转移相关候选基因，它与信号转导或基因表达调控有关。我们通过定量逆转录聚合酶链反应检测了47例手术切除的食管鳞状细胞癌中大鼠mta1基因的人类同源基因MTA1的mRNA表达水平。在47例（34.0%）食管癌中，有16例观察到MTA1 mRNA相对过表达（肿瘤/正常比值≥2）。MTA1 mRNA过表达（T/N比值≥2）的食管肿瘤外膜侵犯（P<0.05）和淋巴结转移（P<0.05）频率显著更高，并且与其余肿瘤相比，其淋巴管受累率往往更高。因此，数据表明MTA1基因可能在食管癌的侵袭和转移中起重要作用。
Zotero 插件