Iguchi H, Imura G, Toh Y, Ogata Y
National Kyushu Cancer Center, Minami-ku, Fukuoka 811-1395, Japan.
Int J Oncol. 2000 Jun;16(6):1211-4. doi: 10.3892/ijo.16.6.1211.
MTA1 has been identified as a metastasis-promoting gene, and its gene expression is correlated with serosal invasion and lymph node metastasis in the gastrointestinal and esophageal cancers. We examined MTA1 mRNA expression levels in 13 cell lines and 23 tumor tissues of pancreatic cancer by quantitative reverse transcription polymerase chain reaction. MTA1 mRNA expression was found in all the cell lines, however its levels were not correlated with the metastatic pontential of each cell line representing hematogenous distant metastasis. In the pancreatic cancer tissues, the overexpression of MTA1 mRNA (tumor/normal ratio >/=1) was observed in 12 out of 23. Pancreatic cancer tissues overexpressing MTA1 mRNA (T/N ratio >/=1) tended to have higher incidence of lymph node metastasis. These results together with previous findings in the gastrointestinal and esophageal cancers suggest that MTA1 might be involved in the progression, particularly in lymph node metastasis of pancreatic cancer.
MTA1已被确定为一种促进转移的基因，其基因表达与胃肠道和食管癌的浆膜侵犯及淋巴结转移相关。我们通过定量逆转录聚合酶链反应检测了13种胰腺癌细胞系和23例胰腺癌肿瘤组织中的MTA1 mRNA表达水平。在所有细胞系中均发现有MTA1 mRNA表达，但其水平与代表血行远处转移的各细胞系的转移潜能无关。在胰腺癌组织中，23例中有12例观察到MTA1 mRNA过表达（肿瘤/正常比值≥1）。MTA1 mRNA过表达（T/N比值≥1）的胰腺癌组织往往有更高的淋巴结转移发生率。这些结果与先前在胃肠道和食管癌中的发现共同表明，MTA1可能参与胰腺癌的进展，尤其是淋巴结转移。
