Livraghi T, Goldberg S N, Lazzaroni S, Meloni F, Solbiati L, Gazelle G S
Department of Radiology, Ospedale Civile, Vimercate, Italy.
Radiology. 1999 Mar;210(3):655-61. doi: 10.1148/radiology.210.3.r99fe40655.
To compare the effectiveness of radio-frequency (RF) ablation with that of percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC).
Eighty-six patients with 112 small (< or = 3-cm-diameter) HCCs underwent RF ablation (42 patients with 52 tumors) or percutaneous ethanol injection (44 patients with 60 tumors). Therapeutic efficacy was evaluated with dual-phase spiral computed tomography performed at least 4 months after treatment.
Complete necrosis was achieved in 47 of 52 tumors with RF ablation (90%) and in 48 of 60 tumors with percutaneous ethanol injection (80%). These results were obtained with an average of 1.2 sessions per tumor with RF ablation and 4.8 sessions per tumor with percutaneous ethanol injection. One major complication (hemothorax that required drainage) and four minor complications (intraperitoneal bleeding, hemobilia, pleural effusion, cholecystitis) occurred in patients treated with RF ablation; no complications occurred in patients treated with percutaneous ethanol injection.
RF ablation results in a higher rate of complete necrosis and requires fewer treatment sessions than percutaneous ethanol injection. However, the complication rate is higher with RF ablation than with percutaneous ethanol injection. RF ablation is the treatment of choice for most patients with HCC.
比较射频（RF）消融术与经皮乙醇注射术治疗小肝细胞癌（HCC）的疗效。
86例患有112个小（直径≤3 cm）HCC的患者接受了RF消融术（42例患者，52个肿瘤）或经皮乙醇注射术（44例患者，60个肿瘤）。治疗后至少4个月进行双期螺旋计算机断层扫描评估治疗效果。
RF消融术治疗的52个肿瘤中有47个（90%）实现了完全坏死，经皮乙醇注射术治疗的60个肿瘤中有48个（80%）实现了完全坏死。RF消融术每个肿瘤平均治疗1.2次，经皮乙醇注射术每个肿瘤平均治疗4.8次。接受RF消融术治疗的患者发生了1例严重并发症（需要引流的血胸）和4例轻微并发症（腹腔内出血、胆道出血、胸腔积液、胆囊炎）；接受经皮乙醇注射术治疗的患者未发生并发症。
与经皮乙醇注射术相比，RF消融术可实现更高的完全坏死率，且所需治疗次数更少。然而，RF消融术的并发症发生率高于经皮乙醇注射术。RF消融术是大多数HCC患者的首选治疗方法。
