Vernon S W, Gritz E R, Peterson S K, Perz C A, Marani S, Amos C I, Baile W F
University of Texas-Houston School of Public Health 77030, USA.
Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 2):353-60.
This report investigates the correlates of intention to find out genetic test results in colorectal cancer patients undergoing genetic counseling and testing for hereditary nonpolyposis colon cancer. Specifically, we investigated whether intention to learn genetic test results was associated with sociodemographic factors, medical history, psychosocial factors, attitudes, beliefs, and decisional considerations related to genetic testing.
Among 342 colorectal cancer patients who went through an informed consent process and gave blood for genetic testing and who were eligible for a psychosocial questionnaire study, 269 cases completed a baseline interview. Patients were contacted in person during a routine clinic visit or by letter and follow-up telephone call and were interviewed either in person or by telephone.
In univariate analysis, intention to learn test results was positively associated with income, quality of life, a belief that being tested will help family members prevent cancer, being worried about carrying an altered gene, and a belief that one has the ability to cope with test results. It was negatively associated with a belief that genetic counseling is too much trouble relative to the benefits. Intention also was positively associated with scales measuring the pros of learning test results and the pros of informing relatives about test results; it was negatively associated with the cons of learning test results. In multivariable analysis, the belief that testing would help family members prevent cancer, being worried about carrying an altered gene, and the pros of learning test results remained statistically associated with intention when other variables were included in the model.
Our findings showed that the positive aspects of genetic testing were more strongly associated with intention than were the negative aspects. They also showed that persons who stated an intention to learn their genetic test results were more likely than persons who did not to affirm both the benefits and the importance of such testing. These results are consistent with the literature on psychosocial aspects of genetic testing for breast cancer.
本报告调查了接受遗传性非息肉病性结直肠癌遗传咨询和检测的结直肠癌患者中，了解基因检测结果意愿的相关因素。具体而言，我们研究了了解基因检测结果的意愿是否与社会人口学因素、病史、心理社会因素、态度、信念以及与基因检测相关的决策考虑因素有关。
在342例经过知情同意程序并提供血液进行基因检测且符合心理社会问卷调查研究条件的结直肠癌患者中，269例完成了基线访谈。在常规门诊就诊期间亲自联系患者，或通过信件和后续电话进行联系，并通过面对面或电话方式进行访谈。
在单变量分析中，了解检测结果的意愿与收入、生活质量、认为检测有助于家庭成员预防癌症的信念、担心携带变异基因以及认为自己有能力应对检测结果呈正相关。它与认为基因咨询相对于益处而言麻烦过多的信念呈负相关。意愿还与衡量了解检测结果的益处和告知亲属检测结果的益处的量表呈正相关；它与了解检测结果的弊端呈负相关。在多变量分析中，当模型纳入其他变量时，认为检测将有助于家庭成员预防癌症的信念、担心携带变异基因以及了解检测结果的益处与意愿在统计学上仍相关。
我们的研究结果表明，基因检测的积极方面比消极方面与意愿的关联更强。它们还表明，表示有意愿了解其基因检测结果的人比没有意愿的人更有可能认可这种检测的益处和重要性。这些结果与关于乳腺癌基因检测心理社会方面的文献一致。
