Chan G S, Yuen S T, Chu K M, Ho J W, Leung S Y, Ho J C
Department of Pathology, Queen Mary Hospital, University of Hong Kong, China.
J Gastroenterol Hepatol. 1999 Apr;14(4):313-6. doi: 10.1046/j.1440-1746.1999.01868.x.
Helicobacter pylori (H. pylori) colonize only foveolar gastric-type mucosa and are associated with active chronic gastritis and peptic ulcer. The aim of this study was to investigate whether H. pylori can also be found in Meckel's diverticulum which contains heterotopic gastric mucosa.
Biopsy specimens of Meckel's diverticulum resected in Queen Mary Hospital, University of Hong Kong, during the 10 year period 1986-1995 were retrieved and reviewed. Those containing gastric heterotopia were examined for the presence of H. pylori, using Warthin-Starry silver stain.
In the 59 cases of Meckel's diverticula studied, 16 were found to contain heterotopic gastric mucosa. Helicobacter pylori were not identified in any of these cases. In one of the 16 patients a concomitant gastric biopsy was performed. Although the gastric mucosa of this patient was heavily colonized by H. pylori, again no H. pylori was found in the heterotopic gastric mucosa in the Meckel's diverticulum.
The absence of H. pylori in all the Meckel's diverticula examined, even when the stomach was heavily colonized by the organisms, suggests that colonization of Meckel's diverticulum by H. pylori is a rare event. This, together with the overall rarity of H. pylori in all reported series of Meckel's diverticulum, argues against its causative role in complications of Meckel's diverticulum.
幽门螺杆菌仅定植于胃小凹型胃黏膜，与活动性慢性胃炎和消化性溃疡相关。本研究的目的是调查在含有异位胃黏膜的梅克尔憩室中是否也能发现幽门螺杆菌。
检索并回顾了1986年至1995年期间在香港大学玛丽医院切除的梅克尔憩室的活检标本。对那些含有胃异位组织的标本，采用沃辛-斯塔里银染色法检测幽门螺杆菌的存在情况。
在研究的59例梅克尔憩室病例中，发现16例含有异位胃黏膜。在这些病例中均未发现幽门螺杆菌。16例患者中有1例同时进行了胃活检。尽管该患者的胃黏膜被幽门螺杆菌大量定植，但在梅克尔憩室的异位胃黏膜中再次未发现幽门螺杆菌。
在所有检查的梅克尔憩室中均未发现幽门螺杆菌，即使胃部被该菌大量定植，这表明幽门螺杆菌定植于梅克尔憩室是一种罕见事件。这一点，连同所有已报道的梅克尔憩室系列中幽门螺杆菌总体罕见的情况，均反驳了其在梅克尔憩室并发症中的致病作用。
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