Ergün Orkan, Celik Ahmet, Akarca Ulus S, Sen Teoman, Alkanat Murat, Erdener Ata
Department of Pediatric Surgery, University Faculty of Medicine, Izmir, Turkey.
J Pediatr Surg. 2002 Nov;37(11):1540-2. doi: 10.1053/jpsu.2002.36180.
BACKGROUND/PURPOSE: Helicobacter pylori is a microorganism known to colonize in gastric type of mucosa and is associated with gastritis and peptic ulceration. The aim of the study was to determine whether colonization of H pylori in heterotopic gastric mucosa plays a role in bleeding of Meckel's diverticulum.
Histopathologic slides of patients who had undergone resection of Meckel's diverticulum in recent 5 years were reexamined for the presence of H pylori in heterotopic gastric mucosa. Polimerase chain reaction (PCR) test was used to trace the genetic material of urease gene and 16s rDNA amplifications for H pylori.
Thirteen of the 30 histopathologic slides of Meckel's diverticula had heterotopic gastric mucosa. Ten of the 13 patients presented with acute bleeding of the diverticula, whereas 3 of them were asymptomatic. None of the 13 gastric mucosa bearing diverticula were colonized with H pylori. PCR was unable to show any trace of genetic material for H pylori.
Although the role of H pylori is well established in the gastric mucosal ulceration, its presence is not essentially required to induce "heterotopic gastritis" that may result in bleeding of the Meckel's diverticulum. .
背景/目的：幽门螺杆菌是一种已知可在胃型黏膜定植的微生物，与胃炎和消化性溃疡有关。本研究的目的是确定幽门螺杆菌在异位胃黏膜中的定植是否在梅克尔憩室出血中起作用。
对最近5年接受梅克尔憩室切除术患者的组织病理切片重新检查，以确定异位胃黏膜中是否存在幽门螺杆菌。采用聚合酶链反应（PCR）检测追踪脲酶基因的遗传物质以及幽门螺杆菌16s rDNA扩增情况。
30例梅克尔憩室组织病理切片中有13例存在异位胃黏膜。13例患者中有10例出现憩室急性出血，3例无症状。13例含憩室的胃黏膜中均未发现幽门螺杆菌定植。PCR未显示出任何幽门螺杆菌遗传物质的痕迹。
虽然幽门螺杆菌在胃黏膜溃疡中的作用已得到充分证实，但在引发可能导致梅克尔憩室出血的“异位胃炎”方面，其存在并非必不可少。
