Hill P, Rode J
Department of Anatomical Pathology, St Vincent's Hospital, Melbourne, Australia.
Pathology. 1998 Feb;30(1):7-9. doi: 10.1080/00313029800169585.
We report a case of a 25-year-old man who presented with a large rectal bleed and positive Meckel's scan followed by surgical excision of a Meckel's diverticulum. The diverticulum was lined by gastric body type mucosa showing evidence of active chronic gastritis associated with the presence of Helicobacter pylori organisms, these being identified immunohistochemically with a specific polyclonal antibody. We have reviewed another 21 cases of Meckel's diverticula removed at St Vincent's Hospital between 1984 and 1997: in nine of these cases the diverticulum was lined by ectopic gastric body type mucosa and in one of these there was an active chronic gastritis associated with Helicobacter pylori. There has been considerable controversy regarding both the presence and significance of Helicobacter organisms in Meckel's diverticula. This is the first study to use immunohistochemistry specifically to identify Helicobacter pylori within two cases of Meckel's diverticula. Both cases demonstrated an active chronic gastritis present within the gastric body type mucosa, thus suggesting that the organisms play a pathogenic role.
我们报告一例25岁男性患者，该患者出现大量直肠出血，梅克尔扫描呈阳性，随后接受了梅克尔憩室切除术。憩室内衬胃体型黏膜，显示存在与幽门螺杆菌相关的活动性慢性胃炎证据，通过特异性多克隆抗体免疫组化鉴定出这些幽门螺杆菌。我们回顾了1984年至1997年间在圣文森特医院切除的另外21例梅克尔憩室病例：其中9例憩室内衬异位胃体型黏膜，其中1例存在与幽门螺杆菌相关的活动性慢性胃炎。关于幽门螺杆菌在梅克尔憩室中的存在及其意义一直存在相当大的争议。这是第一项专门使用免疫组化在两例梅克尔憩室中鉴定幽门螺杆菌的研究。两例均显示胃体型黏膜内存在活动性慢性胃炎，因此提示这些细菌起致病作用。
