Digoutte J P, Girault G
Ann Microbiol (Paris). 1976 Oct;127B(3):429-37.
Venezuelan encephalitis virus is a constant menace to man and to animals, particularly horses. Two as yet unreported strains have been isolated in French Guyana: Ca An 410d (Tonate) and Ca Ar 508 (Cabassou). They are not neurovirulent after peripheral inoculation into adult mice and guinea pigs. Cabassou is not pathogenic for adult mice after intracerebral inoculation. A third strain, Ca Ar 19007, is antigenically identical by complement-fixation with Cabassou, but appears to cross react with other strains, Tonate, when injected intra-peritoneally or sub-cutaneously, protects adult mice against intra-cerebral or intra-peritoneal challenge with Everglades virus. The Ca Ar 19007 isolate causes total protection against Everglades virus if injected intra-peritoneally, but only partial protection by the sub-cutaneous route. Cabassou, on the other hand, if injected intra-peritoneally will protect against intra-cerebral challenge with Everglades. Tonate and Ca Ar 19007 thus appear to be naturally occurring attenuated variants of the Venezuelan encephalitis virus complex, which can protect mice against intra-cerebral infection with neurovirulent strains.
委内瑞拉脑炎病毒对人类和动物，尤其是马匹，始终构成威胁。在法属圭亚那分离出了两种尚未报道过的毒株：Ca An 410d（托纳特）和Ca Ar 508（卡巴苏）。将它们经外周接种到成年小鼠和豚鼠体内后不具有神经毒性。卡巴苏经脑内接种对成年小鼠无致病性。第三种毒株Ca Ar 19007，通过补体结合试验与卡巴苏抗原性相同，但当经腹腔或皮下注射时，似乎与其他毒株托纳特发生交叉反应，能保护成年小鼠抵御大沼泽地病毒的脑内或腹腔内攻击。如果经腹腔注射，Ca Ar 19007分离株能完全保护小鼠抵御大沼泽地病毒，但经皮下途径注射则只能提供部分保护。另一方面，卡巴苏如果经腹腔注射，能保护小鼠抵御大沼泽地病毒的脑内攻击。因此，托纳特和Ca Ar 19007似乎是委内瑞拉脑炎病毒复合体天然存在的减毒株，能够保护小鼠抵御神经毒性毒株的脑内感染。
