Matsumoto M, Shinohara O, Ishiguro H, Shimizu T, Hattori K, Ichikawa M, Yabe H, Kubota C, Yabe M, Kato S
Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa-ken 259-1193, Japan.
Arch Dis Child. 1999 May;80(5):452-4. doi: 10.1136/adc.80.5.452.
To examine the long term effect of bone marrow transplantation (BMT) on ovarian function in girls.
Eighteen girls who underwent BMT before menarche, had been disease free for more than six years, and were over 14 years of age at the time of study were investigated. The preparative regimen consisted of irradiation and chemotherapy. The occurrence of menarche and changes in basal serum follicle stimulating hormone (FSH) concentrations were studied.
Twelve patients achieved menarche at a median age of 12.8 years. Age at transplant was significantly younger in patients who achieved menarche than in those who did not (mean (SD), 7.2 (0.5) v 11.1 (1.7) years). Basal FSH began to rise to menopausal concentrations after 10 years of age, and the girls who did not experience menarche had a sustained rise in FSH concentrations. Among those with raised FSH concentrations, five girls experienced menarche while serum FSH values were decreasing and four achieved menarche while FSH remained raised.
The high incidence of menarche suggests a favourable outcome of ovarian function in girls who undergo BMT at a young age.
研究骨髓移植（BMT）对女童卵巢功能的长期影响。
对18名在月经初潮前接受BMT、疾病缓解超过6年且研究时年龄超过14岁的女童进行调查。预处理方案包括放疗和化疗。研究月经初潮的发生情况以及基础血清促卵泡激素（FSH）浓度的变化。
12例患者月经初潮，中位年龄为12.8岁。月经初潮患者的移植年龄显著低于未月经初潮患者（均值（标准差），7.2（0.5）岁对11.1（1.7）岁）。基础FSH在10岁后开始升至绝经浓度，未经历月经初潮的女童FSH浓度持续升高。在FSH浓度升高的女童中，5名女童在血清FSH值下降时月经初潮，4名女童在FSH仍升高时月经初潮。
月经初潮的高发生率表明，幼年接受BMT的女童卵巢功能预后良好。
