Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS-735, Memphis, TN, 38105, USA,
Curr Osteoporos Rep. 2013 Dec;11(4):329-37. doi: 10.1007/s11914-013-0165-0.
Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therapies, nutritional deficiencies, and reduced physical activity. Accordingly, failure to accrue optimal bone mass during childhood may place survivors at increased risk for deficits in bone density and fracture in later life. Current recommendations for the treatment of bone density decrements among cancer survivors include dietary counseling and supplementation to ensure adequate calcium and vitamin D intake. Few strategies exist to prevent or treat bone loss. Moving forward, studies characterizing the trajectory of changes in bone density over time will facilitate the development of interventions and novel therapies aimed at minimizing bone loss among survivors of childhood cancer.
尽管近年来被诊断患有癌症的儿童的生存率有了显著提高，但幸存者仍有患上与治疗相关的慢性健康问题的风险。在接受癌症治疗的儿童和青少年中，癌症治疗、营养缺乏和体力活动减少可能会影响峰值骨量的获得。因此，如果儿童时期没有获得最佳的骨量，幸存者在以后的生活中可能会面临骨密度下降和骨折的风险增加。目前针对癌症幸存者骨密度下降的治疗建议包括饮食咨询和补充，以确保摄入足够的钙和维生素 D。预防或治疗骨质流失的策略很少。展望未来，描述骨密度随时间变化轨迹的研究将有助于制定干预措施和新疗法，旨在最大限度地减少儿童癌症幸存者的骨质流失。
