转运RNA的生物合成：一张离开细胞核的签证。
Transfer RNA biogenesis: A visa to leave the nucleus.
作者信息
Simos G, Hurt E
机构信息
Biochemie-Zentrum Heidelberg, 69120 Heidelberg, Germany.
出版信息
Curr Biol. 1999 Apr 8;9(7):R238-41. doi: 10.1016/s0960-9822(99)80152-3.
Abstract
Only correctly folded and mature tRNAs can leave the nucleus and enter the cytoplasm. Surprisingly, tRNA-aminoacylation has been found to occur, not only in the cytosol, but also inside the nucleus, where it may act as an additional proofreading step and facilitate the export of 'ready-to-function' aminoacyl-tRNAs.
摘要
只有正确折叠且成熟的转运RNA（tRNA）才能离开细胞核进入细胞质。令人惊讶的是，人们发现tRNA的氨酰化不仅发生在细胞质中，也发生在细胞核内，在细胞核中它可能作为一个额外的校对步骤，并促进“已具备功能”的氨酰tRNA的输出。
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