Wnt及其他信号对LEF-1/TCF转录因子的调控

Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

作者信息

Eastman Q, Grosschedl R

机构信息

Howard Hughes Medical Institute, Department of Microbiology and Immunology, 513 Parnassus Avenue, University of California San Francisco, CA 94143, USA.

出版信息

Curr Opin Cell Biol. 1999 Apr;11(2):233-40. doi: 10.1016/s0955-0674(99)80031-3.

DOI:10.1016/s0955-0674(99)80031-3

PMID:10209158

Abstract

LEF-1/TCF transcription factors mediate a nuclear response to Wnt signals by interacting with beta-catenin. Wnt signaling and other cellular events that increase the stability of beta-catenin result in transcriptional activation by LEF-1/TCF proteins in association with beta-catenin. In the absence of Wnt signaling, LEF-1/TCF proteins repress transcription in association with Groucho and CBP. The LEF-1/TCF transcription factors can also interact with other cofactors and play an architectural role in the assembly of multiprotein enhancer complexes, which may allow for the integration of multiple signaling pathways.

摘要

LEF-1/TCF转录因子通过与β-连环蛋白相互作用介导对Wnt信号的核反应。Wnt信号传导和其他增加β-连环蛋白稳定性的细胞事件导致LEF-1/TCF蛋白与β-连环蛋白结合从而激活转录。在没有Wnt信号传导的情况下，LEF-1/TCF蛋白与Groucho和CBP结合抑制转录。LEF-1/TCF转录因子还可以与其他辅因子相互作用，并在多蛋白增强子复合物的组装中发挥结构作用，这可能允许整合多种信号通路。