Manukova M A
Antibiotiki. 1976 Dec;21(12):1098-104.
When albino mice with experimental staphylococcal sepsis were treated by doxycycline for 10 days, it was noted that the antibiotic had an inhibitory effect on the absorbing capacity of the peritoneal leucocytes with respect to Staph aureus. The decreased digesting capacity of the leucocytes was observed only during the first 5 days from the moment of infection and treatment. The combined use of doxycycline and pentoxyl stimulated the activity and intensity of phagocytosis. The activity values of completed phagocytosis did not change, while the coefficient of the phagocytosis completeness increased as compared to the same values in the animal group treated with doxycycline alone.
当用强力霉素对患有实验性葡萄球菌败血症的白化小鼠进行为期10天的治疗时，发现该抗生素对腹膜白细胞对金黄色葡萄球菌的吸收能力有抑制作用。白细胞消化能力的下降仅在感染和治疗后的前5天观察到。强力霉素和潘托昔（pentoxyl）联合使用可刺激吞噬作用的活性和强度。完全吞噬作用的活性值没有变化，而吞噬作用完成系数与仅用强力霉素治疗的动物组相比有所增加。
