Alekseev A M
Antibiotiki. 1976 Apr;21(4):358-61.
The state of immunological reactivity was studied on 250 albino mice treated with gentamycin and pentoxyl used alone or in combination because of sepsis caused by Ps. aeruginosa. Morphological changes in the spleen and lymph nodes, as well as the dynamics of the agglutinins accumulation in the blood serum were investigated. Gentamycin had no significant effect on the plasmocytal reaction in the lymph nodes and at the same time lowered the number of the immunocompetent cells in the spleen and the titer of agglutinins in the blood serum. The use of gentamycin in combination with pentoxyl had a stimulating effect on transformation of the plasmic cells in the lymphoid organs and resulted in increased titers of agglutinins in the blood serum of the animals treated.
对250只因铜绿假单胞菌败血症而单独或联合使用庆大霉素和潘托昔尔治疗的白化小鼠的免疫反应状态进行了研究。研究了脾脏和淋巴结的形态变化以及血清中凝集素积累的动态。庆大霉素对淋巴结中的浆细胞反应无显著影响，同时降低了脾脏中免疫活性细胞的数量和血清中凝集素的滴度。庆大霉素与潘托昔尔联合使用对淋巴器官中浆细胞的转化有刺激作用，并导致治疗动物血清中凝集素滴度增加。
