Justesen U S, Mygind L H, Pedersen S S, Pedersen C
Odense Universitetshospital, medicinsk afdeling C.
Ugeskr Laeger. 1999 Mar 22;161(12):1747-51.
The purpose of the study was to evaluate the efficacy of treating of HIV infected patients with two nucleoside analogues and one protease inhibitor in clinical practice. Sixty-one patients were included and followed with respect to plasma HIV-RNA, CD4 cell count and side effects up to one year. Median plasma HIV-RNA was reduced from 20,000 to < 200 copies/ml, and the percentage of patients with plasma HIV-RNA < 200 copies per ml increased from 7.5% to 65.2%. The CD4 cell count increased from 180 to 300 x 10(6)/l. Among 49 patients who remained on therapy, the percentage of patients with plasma HIV-RNA < 200 copies/ml increased from 9.8% to 73.7%. It is concluded that triple drug antiretroviral treatment shows significant effects on plasma HIV-RNA and CD4 cell count, and that the results obtained in clinical practice are comparable to results reported from controlled clinical trials.
该研究的目的是评估在临床实践中使用两种核苷类似物和一种蛋白酶抑制剂治疗HIV感染患者的疗效。纳入了61名患者，并对其血浆HIV-RNA、CD4细胞计数及副作用进行了长达一年的随访。血浆HIV-RNA中位数从20,000降至<200拷贝/毫升，血浆HIV-RNA<200拷贝/毫升的患者百分比从7.5%增至65.2%。CD4细胞计数从180增至300×10⁶/升。在49名继续接受治疗的患者中，血浆HIV-RNA<200拷贝/毫升的患者百分比从9.8%增至73.7%。结论是三联抗逆转录病毒治疗对血浆HIV-RNA和CD4细胞计数显示出显著效果，且临床实践中获得的结果与对照临床试验报告的结果相当。
