Griffith N, Howell S, Mason D G
Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford.
Br J Anaesth. 1998 Dec;81(6):865-9. doi: 10.1093/bja/81.6.865.
Midazolam is often used for paediatric premedication. We have compared two methods of administering midazolam intranasally in 44 surgical day-case children allocated randomly to receive midazolam 0.2 mg kg-1 as drops or midazolam 0.1 mg kg-1 from an intranasal spray device. Behaviour was recorded on a four-point scale by the parent, nurse and anaesthetist. Coefficients were obtained representing the change in behaviour score. There was no significant difference in method of administration (coefficient 0.13, P = 0.39). Children were significantly more distressed at the time of premedication and at the time of venous cannulation (coefficients 1.31 and 0.70) than at baseline. There was no significant difference in the assessments between observers. Midazolam by either method was equally effective but acceptability of the premedication was poor in both groups. Intranasal midazolam cannot be recommended as a method for routine premedication of young children.
咪达唑仑常用于小儿术前用药。我们比较了两种鼻内给予咪达唑仑的方法，将44例择期手术的日间手术患儿随机分为两组，一组接受0.2 mg/kg的咪达唑仑滴剂，另一组接受0.1 mg/kg的咪达唑仑鼻喷雾剂。家长、护士和麻醉师采用四点量表记录患儿的行为。计算得出行为评分变化的系数。给药方法无显著差异（系数0.13，P = 0.39）。与基线相比，患儿在术前用药时和静脉穿刺时明显更痛苦（系数分别为1.31和0.70）。观察者之间的评估无显著差异。两种方法使用咪达唑仑的效果相同，但两组患儿术前用药的可接受性都较差。不推荐将鼻内给予咪达唑仑作为幼儿常规术前用药的方法。
