N-乙酰基转移酶1基因多态性影响前列腺癌发生风险。

N-acetyltransferase 1 genetic polymorphism influences the risk of prostate cancer development.

作者信息

Fukutome K, Watanabe M, Shiraishi T, Murata M, Uemura H, Kubota Y, Kawamura J, Ito H, Yatani R

机构信息

Department of Pathology, Mie University School of Medicine, Tsu, Japan.

出版信息

Cancer Lett. 1999 Feb 8;136(1):83-7. doi: 10.1016/s0304-3835(98)00311-5.

DOI:10.1016/s0304-3835(98)00311-5

PMID:10211944

Abstract

The potential involvement of N-acetyltransferase 1 (NAT1) genetic polymorphisms in prostate cancer (PCa) patients was analyzed in 101 patients with PCa and 97 controls with no incidental malignancy. Identification of NAT110, the variant allele associated with the rapid acetylator phenotype was by allele-specific polymerase chain reaction (PCR). When the NAT110 heterozygote and other genotypes without NAT110 allele were considered as low risk genotypes, NAT110/NAT1*10 had a significantly higher risk of PCa (OR = 2.4, 95% CI; 1.0-5.6). If our preliminary results can be confirmed in a larger population, it may be a useful marker for PCa risk.

摘要

在101例前列腺癌（PCa）患者和97例无偶然恶性肿瘤的对照中，分析了N - 乙酰基转移酶1（NAT1）基因多态性在PCa患者中的潜在作用。通过等位基因特异性聚合酶链反应（PCR）鉴定与快速乙酰化表型相关的变异等位基因NAT110。当将NAT110杂合子和其他无NAT110等位基因的基因型视为低风险基因型时，NAT110/NAT1*10的PCa风险显著更高（OR = 2.4，95% CI；1.0 - 5.6）。如果我们的初步结果能在更大规模人群中得到证实，它可能成为PCa风险的一个有用标志物。