神经突延伸的分子机制。
Molecular mechanisms of neurite extension.
作者信息
Valtorta F, Leoni C
机构信息
Department of Neuroscience, San Raffaele Scientific Institute, CNR Center for Cellular and Molecular Pharmacology, Milano, Italy.
出版信息
Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):387-94. doi: 10.1098/rstb.1999.0391.
Abstract
The extension of neurites is a major task of developing neurons, requiring a significant metabolic effort to sustain the increase in molecular synthesis necessary for plasma membrane expansion. In addition, neurite extension involves changes in the subsets of expressed proteins and reorganization of the cytomatrix. These phenomena are driven by environmental cues which activate signal transduction processes as well as by the intrinsic genetic program of the cell. The present review summarizes some of the most recent progress made in the elucidation of the molecular mechanisms underlying these processes.
摘要
神经突的延伸是发育中神经元的一项主要任务，需要大量的代谢努力来维持质膜扩张所需的分子合成增加。此外，神经突延伸涉及表达蛋白亚群的变化和细胞基质的重组。这些现象由激活信号转导过程的环境线索以及细胞的内在遗传程序驱动。本综述总结了在阐明这些过程潜在分子机制方面取得的一些最新进展。
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Growth factors: a role in guiding axons?生长因子：在引导轴突中起作用？
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