Bacci A, Verderio C, Pravettoni E, Matteoli M
CNR-Cellular and Molecular Pharmacology, University of Milano, Italy.
Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):403-9. doi: 10.1098/rstb.1999.0393.
Glial cells represent the most abundant cell population in the central nervous system and for years they have been thought to provide just structural and trophic support to neurons. Recently, several studies were performed, leading to the identification of an active interaction between glia and neurons. This paper focuses on the role played by glial cells at the level of the synapse, reviewing recent data defining how glia is determinant in synaptogenesis, in the modulation of fully working synaptic contacts and in synaptic plasticity.
神经胶质细胞是中枢神经系统中数量最多的细胞群体，多年来人们一直认为它们只为神经元提供结构和营养支持。最近，进行了几项研究，从而确定了神经胶质细胞与神经元之间的活跃相互作用。本文重点关注神经胶质细胞在突触水平所起的作用，回顾了最近的数据，这些数据确定了神经胶质细胞在突触形成、对完全发挥作用的突触接触的调节以及突触可塑性方面是如何起决定性作用的。
