Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.
Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.
Curr Opin Neurobiol. 2019 Feb;54:113-119. doi: 10.1016/j.conb.2018.10.002. Epub 2018 Oct 19.
The dynamic interaction between neurons and glia is a fundamental aspect of developmental neurobiology. Astrocytic processes are extremely complex and can physically surround neuronal synapses where they are involved in regulating neuronal activity and synaptic plasticity. This review describes important roles glial cells play in synapse maturation and stabilization in the developing central nervous system. We highlight recent evidence showing that the motility of astrocytic and radial glial processes is modulated by neuronal signals and is important for normal synapse maturation and function. Examples of glia-derived molecules that influence synapse maturation and stabilization are presented. We close by touching on recent and future trends in neuron-glia research.
神经元和神经胶质之间的动态相互作用是发育神经生物学的一个基本方面。星形胶质细胞的突起极其复杂，可以物理上包围神经元突触，在那里它们参与调节神经元活动和突触可塑性。本综述描述了神经胶质细胞在中枢神经系统发育过程中成熟和稳定突触中的重要作用。我们强调了最近的证据表明，星形胶质细胞和放射状胶质细胞突起的运动受神经元信号的调节，对于正常的突触成熟和功能很重要。介绍了影响突触成熟和稳定的神经胶质衍生分子的例子。最后，我们简要介绍了神经元-神经胶质研究的最新和未来趋势。
