Mosterd A, Hoes A W, de Bruyne M C, Deckers J W, Linker D T, Hofman A, Grobbee D E
Department of Epidemiology & Biostatistics, Erasmus University and University Hospital Rotterdam Dijkzigt, The Netherlands.
Eur Heart J. 1999 Mar;20(6):447-55.
To determine the prevalence of heart failure and symptomatic as well as asymptomatic left ventricular systolic dysfunction in the general population.
In 5540 participants of the Rotterdam Study (age 68.9+/-8.7 years, 2251 men) aged 55-95 years, the presence of heart failure was determined by assessment of symptoms and signs (shortness of breath. ankle oedema and pulmonary crepitations) and use of heart failure medication. In 2267 subjects (age 65.7+/-7.4 years, 1028 men) fractional shortening was measured. The overall prevalence of heart failure was 3.9% (95% CI 3.0+/-4.7) and did not differ between men and women. The prevalence increased with age, with the exception of the highest age group in men. Fractional shortening was higher in women and did not decrease appreciably with age. The prevalence of left ventricular systolic dysfunction (fractional shortening <=25%) was approximately 2.5 times higher in men (5.5%, 95% CI 4.1-7.0) than in women (2.2%, 95% CI 1.4-3.2). Sixty percent of persons with left ventricular systolic dysfunction had no symptoms or signs of heart failure at all.
The prevalence of heart failure is appreciable and does not differ between men and women. The majority of persons with left ventricular systolic dysfunction can be regarded as having asymptomatic left ventricular systolic dysfunction.
确定普通人群中心力衰竭以及有症状和无症状左心室收缩功能障碍的患病率。
在鹿特丹研究的5540名年龄在55 - 95岁的参与者（年龄68.9±8.7岁，男性2251名）中，通过评估症状和体征（呼吸急促、脚踝水肿和肺部啰音）以及心力衰竭药物的使用来确定心力衰竭的存在。在2267名受试者（年龄65.7±7.4岁，男性1028名）中测量了缩短分数。心力衰竭的总体患病率为3.9%（95%可信区间3.0±4.7），男性和女性之间无差异。患病率随年龄增加，男性最高年龄组除外。女性的缩短分数较高，且随年龄没有明显下降。左心室收缩功能障碍（缩短分数≤25%）的患病率在男性（5.5%，95%可信区间4.1 - 7.0）中约为女性（2.2%，95%可信区间1.4 - 3.2）的2.5倍。60%的左心室收缩功能障碍患者根本没有心力衰竭的症状或体征。
心力衰竭的患病率相当可观，男性和女性之间无差异。大多数左心室收缩功能障碍患者可被视为患有无症状左心室收缩功能障碍。
