男性同性恋：与Xq28处微卫星标记无连锁关系。

Male homosexuality: absence of linkage to microsatellite markers at Xq28.

作者信息

Rice G, Anderson C, Risch N, Ebers G

机构信息

Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.

出版信息

Science. 1999 Apr 23;284(5414):665-7. doi: 10.1126/science.284.5414.665.

DOI:10.1126/science.284.5414.665

PMID:10213693

Abstract

Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on the X chromosome. This observation warranted further study and confirmation. Sharing of alleles at position Xq28 was studied in 52 gay male sibling pairs from Canadian families. Four markers at Xq28 were analyzed (DXS1113, BGN, Factor 8, and DXS1108). Allele and haplotype sharing for these markers was not increased over expectation. These results do not support an X-linked gene underlying male homosexuality.

摘要

多条证据表明基因因素与同性恋有关。最有说服力的观察结果是关于男性同性恋与X染色体上微卫星标记的基因连锁报道。这一观察结果值得进一步研究和证实。对来自加拿大家庭的52对男同性恋兄弟对中Xq28位置的等位基因共享情况进行了研究。分析了Xq28处的四个标记（DXS1113、BGN、凝血因子8和DXS1108）。这些标记的等位基因和单倍型共享情况并未高于预期。这些结果不支持存在一个位于X染色体上的基因是男性同性恋的基础。