Turner W J
Department of Psychiatry, State University of New York at Stony Brook, New York 11794, USA.
Arch Sex Behav. 1995 Apr;24(2):109-34. doi: 10.1007/BF01541577.
Despite the absence of phenotypic manifestations in alternating generations characteristic of X-linked disorders, a thesis is presented that a major type of Kinsey grades 5 and 6 male homosexuality is determined by a gene in the Xq28 region. A total of 133 families in 78 kinshps of male and female homosexual probands, in addition to 116 families (including those of 40 famous homosexuals) from the literature, revealed an unbalanced secondary sex ratio in the maternal generation of male, but not of female, homosexuals. On the maternal side, in this study, the ratio of all uncles to all aunts of 90 males homosexuals was 132/209, chi 2 = 8.52, p = 0.004. On the maternal side for the total of all sources, the ratio of uncles to aunts of male homosexuals was 241/367, chi 2 = 13.20; p < 0.0001. The male/female ratio of the total number of maternal sibships bearing homosexuals (310/628: 0.491) was a measure of fetal wastage of the mothers' male sibs; 49%. This ratio was very close to that of the total number of children born to fathers affected with any one of nine Xq28-linked male semilethal conditions (255/508: ratio 0.556); for the difference between the two populations chi 2 = 0.859, p = 0.354. The male/female ratio of the total number of children born to female carriers of any one of these same conditions (1,232/1,062: ratio 1.16), chi 2 = 13.8 p < or = 0.0001, is close to that of the total number of children in homosexual sibships: 511/413, chi 2 = 10.4, p = 0.005. Between the number of children born to Xq28 mothers and to those born of mothers of homosexuals chi 2 = 0.581, p = 0.446. One may readily surmise that the maternal influence so often related to homosexuality may lie in the mother being a genetic carrier, with traits thereto associated. In this study, 65% of the mothers of homosexuals had no or only one live-born brother. Additional support for a genetic hypothesis is found in the occurrence of multiple instances--almost exclusively among maternal relatives--of infertility, spontaneous abortions, miscarriages, stillbirths, remaining single past age 30, and suicide. Of 109 male and 43 female homosexual index cases in the present series there were 6 instances of brother/sister homosexual sibships.(ABSTRACT TRUNCATED AT 400 WORDS)
尽管X连锁疾病的交替世代中不存在表型表现，但有观点认为，金赛性向分级5级和6级的主要类型的男性同性恋是由Xq28区域的一个基因决定的。在78个男性和女性同性恋先证者的亲属关系中，共有133个家庭，此外，从文献中选取了116个家庭（包括40位著名同性恋者的家庭），结果显示，男性同性恋者的母系一代中存在不平衡的二级性别比，而女性同性恋者则不存在。在本研究中，90名男性同性恋者的所有舅舅与所有姨妈的比例在母系一侧为132/209，卡方值=8.52，p=0.004。在所有来源的总体母系一侧，男性同性恋者的舅舅与姨妈的比例为241/367，卡方值=13.20；p<0.0001。生育同性恋者的母系同胞总数的男/女比例（310/628：0.491）是母亲男性同胞胎儿损耗的一个指标；为49%。这个比例与患有9种与Xq28连锁的男性半致死疾病中任何一种的父亲所生子女的总数比例（255/508：比例0.556）非常接近；两个群体之间的差异卡方值=0.859，p=0.354。这些相同疾病中任何一种女性携带者所生子女总数的男/女比例（1232/1062：比例1.16），卡方值=13.8，p≤0.0001，与同性恋同胞总数的比例接近：511/413，卡方值=10.4，p=0.005。Xq28母亲所生子女数量与同性恋者母亲所生子女数量之间的卡方值=0.581，p=0.446。人们可能很容易推测，经常与同性恋相关的母系影响可能在于母亲是基因携带者，并伴有相关特征。在本研究中，65%的同性恋者母亲没有或只有一个存活的兄弟。在不育、自然流产、流产、死产、30岁后单身和自杀等多种情况（几乎只在母系亲属中出现）的发生中，也发现了对基因假说的进一步支持。在本系列的109名男性和43名女性同性恋索引病例中，有6例是兄弟姐妹同性恋同胞关系。（摘要截断于400字）
