Pröls F, Hartner A, Schöcklmann H O, Sterzel R B
Medizinische Klinik IV, Universität Erlangen-Nürnberg, Erlangen, Germany.
Exp Nephrol. 1999 Mar-Apr;7(2):137-46. doi: 10.1159/000020594.
Glomerular mesangial cells play a central role in maintaining structure and function of the glomerular capillary ultrafiltration apparatus. Under physiological and pathological conditions, mesangial cells regulate amount and composition of the surrounding extracellular matrix. Conversely, components of the embedding matrix affect the mesangial cell phenotype. These interactions are mediated via specific cell surface receptors, the best studied group of which is the beta1 integrin family. The beta1 integrins play a role in mesangial cell adhesion, migration, survival and proliferation. Expression and abundance of integrins in healthy and diseased glomeruli and their functions and mediation of signals are discussed in this review. Other factors modulating mesangial cell-matrix interactions, such as antiadhesive proteins, cytokines, disintegrins and nitric oxide, are also considered. The available evidence from in vitro and in vivo studies indicates that receptor-mediated interactions between mesangial cells and the normal or abnormal extracellular matrix regulate the mesangial cell phenotype and thus contribute to normal maintenance of the glomerulus and to remodeling and repair of the glomerular capillary tuft in response to injury.
肾小球系膜细胞在维持肾小球毛细血管超滤装置的结构和功能中起核心作用。在生理和病理条件下，系膜细胞调节周围细胞外基质的数量和组成。相反，包埋基质的成分影响系膜细胞表型。这些相互作用通过特定的细胞表面受体介导，其中研究得最充分的一组是β1整合素家族。β1整合素在系膜细胞黏附、迁移、存活和增殖中起作用。本文综述了健康和患病肾小球中整合素的表达、丰度及其功能和信号介导。还考虑了调节系膜细胞-基质相互作用的其他因素，如抗黏附蛋白、细胞因子、去整合素和一氧化氮。来自体外和体内研究的现有证据表明，系膜细胞与正常或异常细胞外基质之间受体介导的相互作用调节系膜细胞表型，从而有助于肾小球的正常维持以及肾小球毛细血管襻对损伤的重塑和修复。
