Sim E K, Grignani R T, Wong M L, Quek S C, Wong J C, Yip W C, Lee C N
Cardiac Department, National University Hospital, and Gleneagles Medical Centre, Singapore.
Ann Thorac Surg. 1999 Mar;67(3):736-8. doi: 10.1016/s0003-4975(98)01256-9.
From 1986 to March 1997, 128 patients diagnosed to have doubly committed subarterial ventricular septal defects (VSD) were reviewed. Patients with aortic regurgitation (AR), and aortic valve (AV) deformity or a large left-to-right shunt across the VSD were offered operation. Forty-five patients (27 men, 18 women) agreed to surgical closure of their VSDs.
Thirty-eight patients had VSD closure alone, and 7 had an additional AV repair. Other associated defects corrected at operation were closure of atrial septal defects, closure of other ventricular septal defects, ligation of patent ductus arteriosus, and repair of ruptured sinus Valsalva aneurysm.
There was no mortality nor major morbidity associated with operation. In the 26 patients with AR and AV deformity preoperatively, valve repair was performed in 6 patients. The condition of AR improved in 4, and remained unchanged in 22 patients. In the 10 patients with a deformity of the AV and no AR preoperatively, the condition remained unchanged in 5 patients, from whom 1 had valve operation, but progressed in 5 patients postoperatively at a mean follow-up of 6.4 years. In 9 patients with no deformity of the AV and no AR preoperatively, there was no postoperative AR and no progress of valve deformity.
Excellent results were obtained with VSD closure and AV repair. Surgical closure of VSD, if performed before the onset of AV deformity, may prevent progressive AR. If AV repair is performed after the onset of AV deformity, progressive AR may not always be prevented.
对1986年至1997年3月期间诊断为双动脉下室间隔缺损(VSD)的128例患者进行了回顾性研究。对于伴有主动脉瓣反流(AR)、主动脉瓣(AV)畸形或VSD处大量左向右分流的患者,建议进行手术。45例患者(27例男性,18例女性)同意手术闭合其VSD。
38例患者仅进行了VSD闭合术,7例患者还进行了AV修复。手术中矫正的其他相关缺陷包括房间隔缺损闭合、其他室间隔缺损闭合、动脉导管未闭结扎以及主动脉窦瘤破裂修复。
手术无死亡病例,也无严重并发症。术前有AR和AV畸形的26例患者中,6例进行了瓣膜修复。4例患者的AR情况改善,22例患者的情况保持不变。术前有AV畸形但无AR的10例患者中,5例患者的情况保持不变,其中1例进行了瓣膜手术,但在平均随访6.4年时,5例患者术后病情进展。术前无AV畸形且无AR的9例患者,术后无AR,瓣膜畸形也无进展。
VSD闭合和AV修复取得了良好效果。如果在AV畸形出现之前进行VSD手术闭合,可能预防AR的进展。如果在AV畸形出现之后进行AV修复,可能无法总是预防AR的进展。