Singh J, Khare S, Prabha S, Chandra R, Jain D C, Bhatia R, Sokhey J
National Institute of Communicable Diseases, Delhi, India.
Indian Pediatr. 1998 Dec;35(12):1187-91.
To find out the patterns of and the factors, if any, affecting the transplacental transfer of measles antibody.
Comparison of measles antibody titres in mothers with titres in cord blood samples.
Maternal and cord blood samples from 174 full-term pregnant women of middle socio-economic status were tested for hemagglutination inhibition (HI) antibody against measles in Delhi during October 1993 to January 1995. None of the mothers had been immunized against measles.
Antibody were undetectable in both maternal and cord samples in only 4 (2.3%) pairs. Mean maternal titre was found to be 2.94 Log2. Transplacental concentration and dilution were respectively observed in 34% and 26% of the samples. Cord titres were more often higher than the maternal values only if the maternal values were low. Overall, cord/maternal ratio of mean titre (Log2) was found to be 1.06. Although the age of the mother and parity had had no significant bearing on the transplacental transfer of measles antibody, cord titres were significantly more often higher than the maternal values as the birth weight increased (Chi-square for linear trend = 5.4; p = 0.02).
The study failed to show appreciable concentration of measles antibodies across the placenta.
查明麻疹抗体经胎盘转运的模式以及影响这种转运的因素（若有）。
比较母亲的麻疹抗体滴度与脐血样本中的抗体滴度。
1993年10月至1995年1月期间，在德里对174名社会经济地位中等的足月孕妇的母血和脐血样本进行了麻疹血凝抑制（HI）抗体检测。所有母亲均未接种过麻疹疫苗。
仅4对（2.3%）样本的母血和脐血中均未检测到抗体。母亲的平均滴度为2.94 Log2。分别在34%和26%的样本中观察到经胎盘的抗体浓度增加和稀释现象。仅当母亲的抗体滴度较低时，脐血滴度才更常高于母亲的滴度。总体而言，平均滴度（Log2）的脐血/母血比值为1.06。尽管母亲的年龄和胎次对麻疹抗体的经胎盘转运没有显著影响，但随着出生体重增加，脐血滴度显著更常高于母亲的滴度（线性趋势卡方检验=5.4；p = 0.02）。
该研究未能显示麻疹抗体经胎盘有明显的浓度变化。
