麻疹与总IgG的胎盘转运
Transplacental transfer of measles and total IgG.
作者信息
Gonçalves G, Cutts F T, Hills M, Rebelo-Andrade H, Trigo F A, Barros H
机构信息
Instituto Nacional de Saúde Dr Ricardo Jorge, Delegação no Porto, Portugal.
出版信息
Epidemiol Infect. 1999 Apr;122(2):273-9. doi: 10.1017/s0950268899002046.
This study was conducted to evaluate factors affecting the levels of total IgG (tIgG) and measles specific IgG (mIgG) in mother and cord sera, and the efficiency of transplacental transport of tIgG and mIgG. The study was conducted in four hospitals in Oporto, Portugal, where 1539 women and their newborns were enrolled. Measles IgG levels were lower among vaccinated mothers and respective cord sera than among vaccinated counterparts. Cord mIgG was strongly correlated with maternal levels in both vaccinated and unvaccinated groups. Transplacental transport efficiency (TTE) of mIgG decreased with increasing maternal levels, although almost one third of the observed effect was due to measurement error. The TTE was not affected by vaccination status. Monitoring maternal measles antibody levels and maternal vaccination status could be useful to determine when the age for measles vaccination can be reduced.
本研究旨在评估影响母亲和脐带血清中总IgG（tIgG）和麻疹特异性IgG（mIgG）水平的因素，以及tIgG和mIgG的胎盘转运效率。该研究在葡萄牙波尔图的四家医院进行，共纳入了1539名妇女及其新生儿。接种疫苗的母亲及其相应脐带血清中的麻疹IgG水平低于未接种疫苗的对照组。在接种疫苗和未接种疫苗的组中，脐带mIgG与母亲水平均密切相关。尽管观察到的效应中近三分之一归因于测量误差，但mIgG的胎盘转运效率（TTE）随母亲水平的升高而降低。TTE不受疫苗接种状态的影响。监测母亲的麻疹抗体水平和母亲的疫苗接种状态可能有助于确定何时可以降低麻疹疫苗接种年龄。
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