Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious Diseases, University of Antwerp, UA-CDE-R 2.13, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Eur J Pediatr. 2012 Aug;171(8):1167-73. doi: 10.1007/s00431-012-1691-y. Epub 2012 Mar 7.
The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (Euroimmun® anti-mumps Virus AT ELISA, Germany) on samples from 213 mother-child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p = 0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p < 0.0001).
Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (<12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses.
本研究旨在前瞻性队列研究中呈现母体腮腺炎抗体存在的持续时间。在妊娠和 12 个月龄之间的七个时间点，使用商业 ELISA 试验（德国 Euroimmun®抗腮腺炎病毒 AT ELISA）对 213 对母婴对的样本进行了 IgG 抗腮腺炎抗体的分离。使用非线性混合模型对婴儿体内母体抗体的衰减进行建模。基于模型的抗体消失的中位数时间为 3.6 个月。自然免疫的母亲的儿童特异性抗体消失的中位数时间（3.8 个月）和接种疫苗的母亲的儿童特异性抗体消失的中位数时间（2.4 个月）有显著差异（p = 0.025）。母亲的抗体 log 水平和出生体重 log 与婴儿体内母体抗体的持续时间相关（p < 0.0001）。
与自然感染的母亲的儿童相比，接种疫苗的母亲的儿童在生命早期更快地失去母体腮腺炎抗体。如果需要在<12 个月龄时早期（<12 个月）接种麻疹、腮腺炎和风疹联合疫苗，母体腮腺炎抗体预计不会干扰婴儿的体液疫苗反应。
