Blessing K
Department of Pathology, Aberdeen University, Foresterhill, UK.
Histopathology. 1999 Mar;34(3):189-98. doi: 10.1046/j.1365-2559.1999.00672.x.
Benign melanocytic naevi exhibit a wide spectrum of histological appearances. Some share significant clinical and histological features and are recognized as entities. Included among these are pagetoid/junctional Spitz naevus, pigmented spindle cell naevus, halo naevus, recurrent and traumatized naevus, ultraviolet (UV) irradiated naevus, naevus in infants, acral naevus, genital naevus and naevi from other specific anatomic locations. However, there still remains a diagnostic grey area of acquired predominantly junctional naevi with architectural and cytological atypia. Only a small percentage of these will fulfil the criteria for dysplastic naevus if criteria are strictly applied. Therefore, there exists a group of otherwise ordinary acquired naevi with atypical junctional activity, mostly mild, whose biological significance is unclear. In older individuals, although junctional activity in otherwise benign naevi does occur, extra care should be exercised in order to prevent the diagnosis of melanoma in situ being overlooked.
良性黑素细胞痣呈现出广泛的组织学表现。有些具有显著的临床和组织学特征，被视为特定类型。其中包括派杰样/交界性斯皮茨痣、色素性梭形细胞痣、晕痣、复发性和创伤性痣、紫外线（UV）照射痣、婴儿痣、肢端痣、生殖器痣以及来自其他特定解剖部位的痣。然而，对于主要为后天性交界痣且具有结构和细胞学异型性的情况，仍存在诊断上的灰色地带。如果严格应用标准，这些痣中只有一小部分会符合发育异常痣的标准。因此，存在一组其他方面普通的后天性痣，具有非典型交界性活性，大多为轻度，其生物学意义尚不清楚。在老年个体中，虽然在其他方面良性的痣中确实会出现交界性活性，但应格外小心，以免忽略原位黑素瘤的诊断。
