来自台湾海洋海绵Parahigginsia sp.的生物活性倍半萜

Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp.

作者信息

Chen C Y, Shen Y C, Chen Y J, Sheu J H, Duh C Y

机构信息

Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

出版信息

J Nat Prod. 1999 Apr;62(4):573-6. doi: 10.1021/np980491p.

DOI:10.1021/np980491p

PMID:10217711

Abstract

Five new sesquiterpenes, parahigginols A-D (1-4) and parahigginic acid (5), have been isolated from a Taiwanese marine sponge Parahigginsia sp. The structural assignments of the new compounds were based on their spectral data, including 1D and 2D NMR. Biological studies revealed that compounds 2-5 exhibited cytotoxicity against murine P-388 and human KB16, A549, and HT-29 tumor cells.

摘要

从台湾海洋海绵Parahigginsia sp.中分离出了五种新的倍半萜类化合物，对映海扇醇A-D（1-4）和对映海扇酸（5）。新化合物的结构归属基于它们的光谱数据，包括一维和二维核磁共振谱。生物学研究表明，化合物2-5对小鼠P-388和人KB16、A549及HT-29肿瘤细胞具有细胞毒性。