School of Pharmacy, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, China.
School of Pharmacy, Jining Medical University, 669 Xueyuan Road, Rizhao 276800, China.
Molecules. 2022 Oct 30;27(21):7376. doi: 10.3390/molecules27217376.
Marine fungi sp. is an important source of natural active lead compounds with biological and chemical diversity, of which sesquiterpenoids are an extremely important class of bioactive secondary metabolites. In this paper, we review the sources, chemical structures, bioactivity, biosynthesis, and druggability evaluation of sesquiterpenoids discovered from marine fungi sp. since 2008. The species involved include mainly , , , , , and so on, which originate from sponges, marine sediments, algae, mangroves, and corals. In recent years, 268 sesquiterpenoids were isolated from secondary metabolites of marine sp., 131 of which displayed bioactivities such as antitumor, antimicrobial, anti-inflammatory, and enzyme inhibitory activity. Furthermore, the main types of active sesquiterpenoids are bisabolanes, followed by drimanes, nitrobenzoyl, etc. Therefore, these novel sesquiterpenoids will provide a large number of potential lead compounds for the development of marine drugs.
海洋真菌 sp. 是具有生物和化学多样性的天然活性铅化合物的重要来源，其中倍半萜是一类极其重要的生物活性次生代谢物。本文综述了自 2008 年以来从海洋真菌 sp.中发现的倍半萜的来源、化学结构、生物活性、生物合成和可药性评价。涉及的种主要有，，，，，等，它们来源于海绵、海洋沉积物、藻类、红树林和珊瑚。近年来，从海洋 sp.的次生代谢产物中分离得到 268 种倍半萜，其中 131 种具有抗肿瘤、抗菌、抗炎和酶抑制活性等生物活性。此外，活性倍半萜的主要类型为倍半水芹烷，其次为二瑞烷、硝基苯甲酰等。因此，这些新型倍半萜将为海洋药物的开发提供大量潜在的先导化合物。
