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对肿瘤抗性的遗传控制。

Genetic control of resistance to tumors.

作者信息

Phillips-Quagliata J M, Walker M C

出版信息

Am J Pathol. 1978 Nov;93(2):487-98.

PMID:102205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2018389/
Abstract

Hybrid resistance to a BALB/c plasmacytoma, MPC-11, has been investigated. The results indicate that heterozygosity within the H-2 complex is neither necessary nor sufficient for resistance to be observed. However, in the presence of a single gene or gene complex which segregates independently of H-2, differential effects of various H-2 haplotypes can be seen. Resistance is radiation-sensitive and silica-insensitive and probably depends on active immune responses. The data also suggest that production by a hybrid of endogenous viral antigens with certain type-specific determinants shared with viral antigens expressed on the tumor may interfere with resistance. The mechanism for this is not understood but might involve tolerance, suppression, or enhancing antibody.

摘要

对BALB/c浆细胞瘤MPC-11的杂种抗性进行了研究。结果表明，H-2复合体内的杂合性对于观察到抗性既非必要条件也非充分条件。然而，在存在一个与H-2独立分离的单基因或基因复合体的情况下，可以看到各种H-2单倍型的差异效应。抗性对辐射敏感而对二氧化硅不敏感，可能取决于活跃的免疫反应。数据还表明，杂种产生的具有与肿瘤上表达的病毒抗原共有的某些型特异性决定簇的内源性病毒抗原可能会干扰抗性。其机制尚不清楚，但可能涉及耐受性、抑制或增强抗体。

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本文引用的文献

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Resistance of H-2 heterozygous mice to parental tumors. II. Characterization of Hh-1 controlled hybrid resistance to syngeneic fibrosarcomas and the EL-4 lymphoma.H-2杂合小鼠对亲代肿瘤的抗性。II. Hh-1控制的对同基因纤维肉瘤和EL-4淋巴瘤的杂种抗性的特征
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10
Relationships of gp70 of MuLV envelopes to gp70 components of mouse lymphocyte plasma membranes.鼠白血病病毒包膜糖蛋白70（gp70）与小鼠淋巴细胞质膜gp70成分的关系。
J Exp Med. 1978 Apr 1;147(4):1280-4. doi: 10.1084/jem.147.4.1280.

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