Ly-4，一个决定小鼠淋巴细胞细胞表面同种异体抗原的新基因座。
Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice.
作者信息
Snell G D, Cherry M, McKenzie I F, Bailey D W
出版信息
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11. doi: 10.1073/pnas.70.4.1108.
Abstract
A new locus is described that determines an alloantigen on the surface of lymphocytes. It differs from loci previously described in that the corresponding antibody, at least in most antisera, reacts almost exclusively with node lymphocytes, and weakly or not at all with thymuslymphocytes. Positive strains include C57BL/6, C57BL/10, C57L, C57BR/cd, and RF; negative strains include BALB/c, C3H, and SJL. The symbol Ly-4 is assigned, with the C57BL/6 allele being Ly-4(b), and the BALB/c allele Ly-4(a).
摘要
描述了一个新的基因座，它决定淋巴细胞表面的一种同种异体抗原。它与先前描述的基因座不同之处在于，相应的抗体，至少在大多数抗血清中，几乎只与淋巴结淋巴细胞发生反应，而与胸腺淋巴细胞反应微弱或根本不反应。阳性菌株包括C57BL/6、C57BL/10、C57L、C57BR/cd和RF；阴性菌株包括BALB/c、C3H和SJL。指定符号为Ly-4，C57BL/6等位基因为Ly-4(b)，BALB/c等位基因为Ly-4(a)。
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本文引用的文献
1
CYTOTOXIC TEST FOR DEMONSTRATION OF MOUSE ANTIBODY.用于证明小鼠抗体的细胞毒性试验。
Methods Med Res. 1964;10:39-47.
2
STUDIES ON ANTIBODY PRODUCTION. XI. VARIATION IN THE SECONDARY RESPONSE AS A FUNCTION OF THE LENGTH OF THE INTERVAL BETWEEN TWO ANTIGENIC STIMULI.抗体产生的研究。十一。二次反应的变化作为两种抗原刺激之间间隔时间长度的函数。
J Exp Med. 1964 Dec 1;120(6):1041-9. doi: 10.1084/jem.120.6.1041.
3
TEMPORAL STUDIES ON SUPPRESSION BY X-RAY OF ADAPTATION FOR THE SECONDARY ANTIBODY RESPONSE.关于X射线对二次抗体应答适应性抑制的时间研究。
J Immunol. 1964 Mar;92:425-30.
4
H-5.A AND H-6.A, TWO MOUSE ISOANTIGENS ON RED CELLS AND TISSUES DETECTED SEROLOGICALLY.H-5.A和H-6.A，两种通过血清学检测出的存在于红细胞和组织上的小鼠同种抗原。
Transplantation. 1963 Jul;1:270-83. doi: 10.1097/00007890-196301030-00002.
5
Antigenic activity of various tissues in transplantation immunity.移植免疫中各种组织的抗原活性。
J Immunol. 1961 Mar;86:345-53.
6
Studies on a substance that promotes tumor homograft survival (the enhancing substance); its distribution and some properties.关于一种促进肿瘤同种移植存活的物质（增强物质）的研究；其分布及一些特性。
J Exp Med. 1957 Feb 1;105(2):125-39. doi: 10.1084/jem.105.2.125.
7
A cytosieve permitting sterile preparation of suspensions of tumor cells for transplantation.一种用于无菌制备用于移植的肿瘤细胞悬液的细胞筛。
J Natl Cancer Inst. 1953 Jun;13(6):1511-5.
8
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Immunology. 1965 Sep;9(3):287-300.
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