Istvan J A, Lee W W, Buist A S, Connett J E
Oregon Health Sciences University and the University of Minnesota, Minneapolis, MN, USA.
Am Heart J. 1999 May;137(5):928-31. doi: 10.1016/s0002-8703(99)70418-7.
In laboratory research, nicotine administration is associated with increases in blood pressure. In epidemiologic research, however, the amount of reported cigarette smoking has no consistent relation with blood pressure. The objective of this study was to examine the relation of a nicotine metabolite (salivary cotinine) to systolic and diastolic blood pressure in current smokers being screened for entry to a clinical trial.
Data were obtained from 5164 middle-aged cigarette smokers during screening for the Lung Health Study. Multiple linear regression was used to examine the association of salivary cotinine and number of cigarettes smoked per day to systolic and diastolic blood pressure with age, body mass, years of education, alcohol intake, and recent caffeinated beverage use controlled in all analyses. Although smoking frequency was unrelated to blood pressure, salivary cotinine was related to greater systolic blood pressure in both men and women and greater diastolic blood pressure in men.
The association between salivary cotinine and blood pressure in these analyses suggests that long-term nicotine exposure may be related to modest elevations in blood pressure in cigarette smokers.
在实验室研究中，给予尼古丁与血压升高有关。然而，在流行病学研究中，报告的吸烟量与血压之间没有一致的关系。本研究的目的是在筛选进入一项临床试验的当前吸烟者中，检查尼古丁代谢物（唾液可替宁）与收缩压和舒张压的关系。
数据来自于肺部健康研究筛选期间的5164名中年吸烟者。在所有分析中，采用多元线性回归来检查唾液可替宁和每日吸烟量与收缩压和舒张压的关联，并对年龄、体重、受教育年限、酒精摄入量和近期含咖啡因饮料的饮用情况进行了控制。虽然吸烟频率与血压无关，但唾液可替宁与男性和女性的收缩压升高以及男性的舒张压升高有关。
这些分析中唾液可替宁与血压之间的关联表明，长期接触尼古丁可能与吸烟者血压适度升高有关。
