[口腔黏膜皮肤移植中的皮脂腺增生（福代斯病）：45年随访]
[Hyperplasia of sebaceous glands (Fordyce's disease) in an oral mucocutaneous graft: 45-year follow-up].
作者信息
Landenberger H, Siepmann K, Rohrbach J M
机构信息
Abteilung I (Allgemeine Augenheilkunde mit Poliklinik), Universitäts-Augenklinik.
出版信息
Klin Monbl Augenheilkd. 1999 Mar;214(3):185-7. doi: 10.1055/s-2008-1034774.
BACKGROUND
Diffuse sebaceous gland hyperplasia in transplanted buccal mucosa is a very rare condition. We report on a further patient with this entity.
PATIENT
In 1953, a now 68-year-old man suffered a severe alkali burn. Transplantation of oral mucosa was performed that same day in order to prevent perforation of the eye. Over the following 45 years, the patient developed multiple yellowish nodules within the grafts. Histologically, these nodules proved to be normally differentiated sebaceous glands.
CONCLUSIONS
Diffuse sebaceous gland hyperplasia originating from within oral mucosa and developing over an extended period of time is a clinical entity known as Fordyce's disease. It is this a late complication of mucocutaneous transplantation, and although it constitutes mainly a problem of cosmesis, functionally it can lead to aberrant secretion of sebum.
背景
移植颊黏膜中弥漫性皮脂腺增生是一种非常罕见的情况。我们报告了另一例患有该病症的患者。
患者
1953年，一名现年68岁的男性遭受了严重的碱烧伤。当天进行了口腔黏膜移植以防止眼球穿孔。在接下来的45年里，患者在移植组织内出现了多个淡黄色结节。组织学检查显示，这些结节为正常分化的皮脂腺。
结论
源自口腔黏膜并在较长时间内发展的弥漫性皮脂腺增生是一种称为福代斯病的临床病症。这是皮肤黏膜移植的晚期并发症，虽然它主要是一个美容问题，但在功能上它可导致皮脂异常分泌。
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