Lukkarinen J A, Gröhn O H, Alhonen L I, Jänne J, Kauppinen R A
NMR Research Group, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.
Brain Res. 1999 May 1;826(2):325-9. doi: 10.1016/s0006-8993(99)01327-x.
Ornithine decarboxylase (ODC) transgenic and alpha-difluoromethyl ornithine (DFMO)-treated rats were exposed to transient middle cerebral occlusion (MCAO) to examine the role of intraischaemic ODC-activity on the evolution of ischaemia-reperfusion damage. Magnetic resonance imaging (MRI) data show that the damage develops slower in ODC transgenic than in DFMO-treated rats, which is not caused by a difference in perfusion. Furthermore, infarct volumes are smaller in the former animals one day later. These data support the idea of endogenous neuroprotective action of ODC.
将鸟氨酸脱羧酶（ODC）转基因大鼠和用α-二氟甲基鸟氨酸（DFMO）处理的大鼠暴露于短暂性大脑中动脉闭塞（MCAO），以研究缺血区内ODC活性在缺血再灌注损伤演变过程中的作用。磁共振成像（MRI）数据显示，ODC转基因大鼠的损伤发展速度比DFMO处理的大鼠慢，这并非由灌注差异所致。此外，一天后前一组动物的梗死体积更小。这些数据支持ODC具有内源性神经保护作用这一观点。
