Lester N V, Newell S M, Hill R C, Lanz O I
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
Vet Radiol Ultrasound. 1999 Mar-Apr;40(2):174-8. doi: 10.1111/j.1740-8261.1999.tb01905.x.
Diagnosis of insulin-secreting tumors of the pancreas can usually be made on the basis of endocrine testing and exclusion of other causes of hyperinsulinism. In dogs, these tumors have a poor long-term prognosis due to a high rate of metastases and recurrence; staging (and therefore prognosticating) is difficult and usually done at the time of surgery. The purpose of this article is to describe a canine patient with an insulinoma, discuss the diagnostic imaging options for tumor evaluation and mention future directions for therapy. Insulinoma was suspected in an 8-year-old intact male Irish Setter. Somatostatin receptor scintigraphy using indium In-111 pentetreotide was performed and an area of increased radiopharmaceutical accumulation was found craniomedial to the right kidney. At surgery a small mass lesion in the pancreas and a larger, closely associated mass involving a mesenteric lymph node were removed. Histopathology confirmed the diagnosis of insulinoma with regional lymph node metastasis. The dog recovered from surgery and remained normal fourteen months later.
胰腺胰岛素分泌肿瘤的诊断通常可基于内分泌检测以及排除其他导致高胰岛素血症的原因来进行。在犬类中，由于转移和复发率高，这些肿瘤的长期预后较差；分期（以及由此进行预后评估）很困难，通常在手术时进行。本文的目的是描述一例患有胰岛素瘤的犬类患者，讨论用于肿瘤评估的诊断性成像选项，并提及未来的治疗方向。一只8岁未绝育的雄性爱尔兰赛特犬被怀疑患有胰岛素瘤。使用铟In-111喷替肽进行了生长抑素受体闪烁扫描，在右肾颅内侧发现了放射性药物积聚增加的区域。手术中切除了胰腺中的一个小肿块病变以及一个较大的、与之紧密相连的累及肠系膜淋巴结的肿块。组织病理学证实为胰岛素瘤伴区域淋巴结转移。这只狗手术后康复，14个月后仍保持正常。
