Blondeau J M, Yaschuk Y, Suter M, Vaughan D
Division of Clinical Microbiology, Saskatoon District Health and St Paul's Hospital (Grey Nuns) and the University of Saskatchewan, Saskatoon, Canada.
J Antimicrob Chemother. 1999 Mar;43 Suppl A:3-23. doi: 10.1093/jac/43.suppl_1.3.
A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against > or = 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had > or = 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxime and ticarcillin/clavulanate, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime, 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, five agents had activity against > or = 90% of all 1921 urinary tract pathogens tested (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had > or = 95% activity against Enterobacteriaceae from urinary tract infection (ciprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen agents had activity against > or = 95% of Staphylococcus aureus strains. Susceptibility of Pseudomonas aeruginosa isolates ranged from 2% to 91%.
来自加拿大48个医疗中心的总共3903种病原体针对19种抗菌药物进行了测试。五种药物对所有1982种测试的呼吸道病原体中的≥90%表现出活性（环丙沙星，90%；头孢哌酮，91%；替卡西林/克拉维酸，92%；头孢他啶和亚胺培南，各93%）。九种药物对呼吸道感染的肠杆菌科细菌有≥90%的活性（头孢噻肟和替卡西林/克拉维酸，各90%；氨曲南、头孢唑肟和头孢曲松，各91%；头孢他啶，93%；环丙沙星，97%；亚胺培南和奈替米星，各98%）。同样，五种药物对所有1921种测试的泌尿道病原体中的≥90%表现出活性（环丙沙星和替卡西林/克拉维酸，各90%；头孢哌酮和奈替米星，各91%；亚胺培南，99%）。九种药物对泌尿道感染的肠杆菌科细菌有≥95%的活性（环丙沙星，95%；头孢替坦，97%；氨曲南、头孢噻肟、头孢他啶、头孢唑肟、头孢曲松和奈替米星，各98%；亚胺培南，99%）。十七种药物对≥95%的金黄色葡萄球菌菌株有活性。铜绿假单胞菌分离株的敏感性范围为2%至91%。
