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The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.αv整合素在血管生成过程中的作用：对潜在作用机制及临床进展的见解。
J Clin Invest. 1999 May;103(9):1227-30. doi: 10.1172/JCI6869.
2
The role of alphav integrins during angiogenesis.αv整合素在血管生成过程中的作用。
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Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.在缺乏所有αv整合素的小鼠中，广泛的血管生成、血管新生和器官发生先于致死性出现。
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本文引用的文献

1
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.β3整合素缺陷小鼠是一种用于研究血小板无力症的模型，表现出胎盘缺陷和存活率降低。
J Clin Invest. 1999 Jan;103(2):229-38. doi: 10.1172/JCI5487.
2
Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist.用αvβ3拮抗剂治疗的兔子中血管生成减少及关节炎疾病减轻。
J Clin Invest. 1999 Jan;103(1):47-54. doi: 10.1172/JCI3756.
3
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.在缺乏所有αv整合素的小鼠中，广泛的血管生成、血管新生和器官发生先于致死性出现。
Cell. 1998 Nov 13;95(4):507-19. doi: 10.1016/s0092-8674(00)81618-9.
4
Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.细胞黏附受体介导的信号转导与信号调节：整合素、钙黏蛋白、免疫球蛋白细胞黏附分子及选择素的作用
Pharmacol Rev. 1998 Jun;50(2):197-263.
5
Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging.通过αVβ3靶向磁共振成像在体内检测肿瘤血管生成
Nat Med. 1998 May;4(5):623-6. doi: 10.1038/nm0598-623.
6
Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis.血管生成过程中持续的丝裂原活化蛋白激酶活性对整合素αvβ3的需求。
J Cell Biol. 1998 Mar 9;140(5):1255-63. doi: 10.1083/jcb.140.5.1255.
7
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity.PEX（一种具有整合素结合活性的非催化金属蛋白酶片段）对血管生成的破坏作用。
Cell. 1998 Feb 6;92(3):391-400. doi: 10.1016/s0092-8674(00)80931-9.
8
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.血管生成过程中血管细胞整合素αVβ3对p53活性和p21WAF1/CIP1表达的抑制作用
J Clin Invest. 1996 Jul 15;98(2):426-33. doi: 10.1172/JCI118808.
9
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.通过与整合素αvβ3相互作用，基质金属蛋白酶MMP-2定位于侵袭性细胞表面。
Cell. 1996 May 31;85(5):683-93. doi: 10.1016/s0092-8674(00)81235-0.
10
Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization.皮下注射玻连蛋白受体型整合素的环肽拮抗剂可抑制视网膜新生血管形成。
Nat Med. 1996 May;2(5):529-33. doi: 10.1038/nm0596-529.

The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.

作者信息

Eliceiri B P, Cheresh D A

机构信息

Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

J Clin Invest. 1999 May;103(9):1227-30. doi: 10.1172/JCI6869.

DOI:10.1172/JCI6869
PMID:10225964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC408360/
Abstract
摘要