Mottu F, Rüfenacht D A, Doelker E
School of Pharmacy, Department of Pharmaceutical Technology, University of Geneva, Switzerland.
Invest Radiol. 1999 May;34(5):323-35. doi: 10.1097/00004424-199905000-00001.
The aim of this review is to give an overview and some insight into different radiopaque polymeric materials that are currently used as medical implants or inserts. The advantages and limitations of each radiopaque polymeric material are summarized. The main method used to make medical implants radiologically visible is based on blending polymers with conventional radiopaque agents, blends which usually are a physical mixture of acrylic derivatives and inorganic salts. Other methods reported involve either the formation of single-phase radiopaque polymer salt complexes somehow preventing the release of the radiopacifying element by entrapment of the complex in a crosslinked network, or radiopaque polymerized monomers characterized by a radiopacifying element associated with the monomer unit prior to polymerization. In the near future, research will certainly concentrate on biocompatible radiopaque polymers with covalently bound opaque elements leading to stable polymers with properties equivalent to the nonopaque, parent polymer.
本综述的目的是概述并深入了解目前用作医疗植入物或插入物的不同不透射线聚合物材料。总结了每种不透射线聚合物材料的优缺点。使医疗植入物在放射学上可见的主要方法是将聚合物与传统的不透射线剂混合，这种混合物通常是丙烯酸衍生物和无机盐的物理混合物。报道的其他方法包括以某种方式形成单相不透射线聚合物盐络合物，通过将络合物截留在交联网络中来防止不透射线元素的释放，或者是在聚合前具有与单体单元相关联的不透射线元素的不透射线聚合单体。在不久的将来，研究肯定会集中在具有共价结合的不透射线元素的生物相容性不透射线聚合物上，从而得到性能与非不透射线母体聚合物相当的稳定聚合物。
