Suslova Evgeniya V, Shashurin Denis A, Maslakov Konstantin I, Kupreenko Stepan Yu, Luneva Tatyana O, Medvedev Oleg S, Chelkov Georgy A
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1 Bld. 3, 119991 Moscow, Russia.
Faculty of Medicine, Lomonosov Moscow State University, Lomonosovsky Ave. 27 Bld. 10, 119991 Moscow, Russia.
Gels. 2024 Dec 8;10(12):807. doi: 10.3390/gels10120807.
Hydrogels have a wide range of medical applications, including use within implantable systems. However, when used in implants, their visibility under conventional medical imaging techniques is limited, creating safety risks for patients. In the current work, we assessed the possibility of enhancing hydrogels using Ln-based contrasting agents to facilitate their visualization in photon-counting computed tomography (PCCT). The contrast enhancement of gelatin, polyacrylamide (PAM), and silicone shells of implants was assessed. A novel synthetic route for producing cross-linked nanosized LnO with polyacrylamide was proposed and discussed in detail. Several prototypes of silicone implants, including silicone shell and gelatin or PAM filling with different combinations of contrasting agents, were produced and assessed in phantom PCCT studies.
水凝胶在医学领域有广泛应用，包括用于植入式系统。然而，当用于植入物时，它们在传统医学成像技术下的可视性有限，给患者带来安全风险。在当前工作中，我们评估了使用基于镧系元素的造影剂增强水凝胶，以便在光子计数计算机断层扫描（PCCT）中实现其可视化的可能性。评估了明胶、聚丙烯酰胺（PAM）以及植入物硅胶壳的造影增强效果。提出并详细讨论了一种用聚丙烯酰胺制备交联纳米尺寸氧化镧的新合成路线。制作了几种硅胶植入物原型，包括硅胶壳以及填充有不同造影剂组合的明胶或PAM，并在体模PCCT研究中进行了评估。
