Birek C, Grandhi R, McNeill K, Singer D, Ficarra G, Bowden G
Faculty of Dentistry, University of Manitoba, Canada.
J Oral Pathol Med. 1999 May;28(5):197-203. doi: 10.1111/j.1600-0714.1999.tb02024.x.
A causative role for Helicobacter pylori (H. pylori) in the pathogenesis of oral mucosal ulcerations has been suggested previously. We have adopted the polymerase chain reaction (PCR) as a rapid and sensitive means to detect H. pylori in swabs of recurrent oral aphthous ulcers and in samples of other oral sites. Of the oral aphthous ulcer samples, 32 (71.8%) were found to be positive, while the saliva and plaque samples (most of them taken from the patients with aphthous ulcers) were consistently negative for H. pylori DNA, as detected by the PCR assay. Only two of the swab samples from the tongue (collected at the time of concurrent, H. pylori-positive oral aphthous ulcers) were found to be positive. The data suggest that H. pylori may be associated frequently with recurrent oral aphthous ulcers, and are consistent with previous studies indicating that saliva and plaque are not likely sources of contamination with this microorganism. There was no apparent correlation with HIV status (infection with human immunodeficiency virus). The possible pathogenic significance of Helicobacter pylori in oral ulcerations is discussed.
先前已有研究表明幽门螺杆菌（H. pylori）在口腔黏膜溃疡发病机制中具有致病作用。我们采用聚合酶链反应（PCR）作为一种快速且灵敏的方法，来检测复发性口腔阿弗他溃疡拭子及其他口腔部位样本中的幽门螺杆菌。在口腔阿弗他溃疡样本中，32份（71.8%）检测呈阳性，而通过PCR检测发现，唾液和菌斑样本（其中大部分取自阿弗他溃疡患者）中幽门螺杆菌DNA始终呈阴性。仅两份来自舌头的拭子样本（在同时发生幽门螺杆菌阳性的口腔阿弗他溃疡时采集）检测呈阳性。数据表明幽门螺杆菌可能经常与复发性口腔阿弗他溃疡相关，并且与先前研究一致，即唾液和菌斑不太可能是这种微生物的污染来源。与HIV状态（人类免疫缺陷病毒感染）无明显相关性。本文讨论了幽门螺杆菌在口腔溃疡中的可能致病意义。
