Shimoyama T, Horie N, Kato T, Kaneko T, Komiyama K
Department of Oral Surgery, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan.
J Oral Sci. 2000 Dec;42(4):225-9. doi: 10.2334/josnusd.42.225.
Helicobacter pylori is an important pathogen involved in the development of gastrointestinal ulcers, but its involvement in oral ulcerous lesions is unclear. As culture is generally recognized as the gold standard for diagnosis of H. pylori infection, we employed this approach to assess the association of H. pylori with oral mucosal ulcerations. Samples were collected from patients with oral mucosal ulcerative disorders: 12 cases of recurrent aphthous stomatitis (RAS), 7 cases of herpes simplex virus (HSV) stomatitis, and 3 cases of erosive lichen planus (LP). Serum IgG antibodies against H. pylori were examined in all cases. All of the RAS and erosive LP cases were culture-negative for H. pylori, while two cases of HSV stomatitis were positive. The two culture-positive cases were also seropositve for the H. pylori antigen. It is suggested that H. pylori might not have a direct association with oral ulcerations. However, H. pylori in the oral cavity might exist in a non-culturable coccoid state without productive infection, and might form colonies only under special conditions such as HSV infection.
幽门螺杆菌是参与胃肠道溃疡发生发展的一种重要病原体，但其与口腔溃疡性病变的关系尚不清楚。由于培养通常被认为是诊断幽门螺杆菌感染的金标准，我们采用这种方法来评估幽门螺杆菌与口腔黏膜溃疡的关联。从患有口腔黏膜溃疡性疾病的患者中采集样本：12例复发性阿弗他口炎（RAS）、7例单纯疱疹病毒（HSV）口炎和3例糜烂性扁平苔藓（LP）。对所有病例检测了抗幽门螺杆菌的血清IgG抗体。所有RAS和糜烂性LP病例的幽门螺杆菌培养均为阴性，而2例HSV口炎病例为阳性。这2例培养阳性病例的幽门螺杆菌抗原血清学检测也呈阳性。提示幽门螺杆菌可能与口腔溃疡无直接关联。然而，口腔中的幽门螺杆菌可能以不可培养的球状体状态存在而无感染活性，并且可能仅在诸如HSV感染等特殊条件下形成菌落。
